Paper      Book or Book Chapter     Review

Klimovich A & TCG Bosch (2018) Rethinking the role of the nervous system: lessons from the Hydra holobiont. BioEssays, in press

Hamada M, Schröder K, Bathia J, Kürn U, Fraune S, Khalturina M, Khalturin K, Shinzato  C, Satoh N, Bosch TCG (2018) Metabolic co-dependence drives the evolutionarily ancient Hydra-Chlorella symbiosis. eLife, in press

Klimovich A, Rehm A, Wittlieb J, Herbst E, Benavente R, Bosch TC, . Non-senescent Hydra tolerates severe disturbances in the nuclear lamina. Aging (Albany NY). 2018; 10:951-972. https://doi.org/10.18632/aging.101440

Rees T, TCG Bosch, AE Douglas (2018) How the Microbiome Challenges our Concept of Self. PLoS Biol. 16(2):e2005358

Bang, C, Dagan T, Deines P, Dubilier N, Duschl WJ, Fraune S, Hentschel U, Hirt H, Hülter N, Lachnit T, Picazo D, Pita L, Pogoreutz C, Radecker N, Saad MM, Schmitz RA, Schulenburg H, Voolstra CR, Weiland-Brauer N, Ziegler M, Bosch TCG (2018). Metaorganisms in extreme environments: do microbes play a role in organismal adaptation? Zoology 127 (2018), 1-19

Wein T, Dagan T, Fraune S, TCG Bosch, Burkhard T, Reusch H, NF Hülter (2018) Carrying capacity and colonization dynamics of the Hydra host habitat. Front. Microbiol, 9:443.

Mortzfeld BM, Taubenheim J, Fraune S, Klimovich AV, Bosch TCG (2018). Stem cell transcription factor FoxO controls microbiome resilience in Hydra. Front Microbiol., 9:629.

Li X-Y, Lachnit T, Fraune S, Bosch TCG, Traulsen A, Sieber M (2017) Temperate phages as self-replicating weapons in bacterial competition. J. R. Soc. Interface 14:20170563 

Murillo-Rincon AP, Klimovich A, Pemöller E, Taubenheim J, Mortzfeld B, Augustin R, Bosch TCG (2017) Spontaneous body contractions are modulated by the microbiome of Hydra. Sci Rep. 7(1):15937 

Pietschke C, C Treitz, S Forêt, A Schultze, S Künzel, A Tholey, T Bosch, S Fraune (2017) Host modification of a bacterial quorum sensing signal induces a phenotypic switch in bacterial symbionts. Proc Natl Acad Sci US, 114(40):E8488-E8497

Augustin R, K Schröder, AP Murillo Rincón, S Fraune, F Anton-Erxleben, E-M Herbst, J Wittlieb1, M Schwentner, J Grötzinger, TM Wassenaar, TCG Bosch (2017) A secreted antibacterial neuropeptide shapes the microbiome in Hydra. Nature Comm., 8(1):69

Mortzfeld B and TCG Bosch (2017) Eco-Ageing: stem cells and microbes are controlled by ageing antagonist FoxO. Current Opinion in Microbiology, 38:181-187

Deines P, T Lachnit and TCG Bosch (2017) Competing forces maintain the Hydra metaorganism. Immunol Reviews, 279(1):123-136

Bosch T.C.G., A. Klimovich, T. Domazet-Lošo, S. Gründer, T.W. Holstein, G. Jékely, D.J. Miller, A.P. Murillo-Rincon, F. Rentzsch, G.S. Richards, K. Schröder, U. Technau, R. Yuste (2017) Back to the Basics: Cnidarians Start to Fire. Trends in Neurosciences, 40(2): 92 – 105

Augustin R and TCG Bosch (2016) Revisiting the Cutaneous Epithelium: Insights from a Nontraditional Model System. Akt Dermatol 42: 414-420

Schröder K and TCG Bosch (2016) The Origin of Mucosal Immunity: Lessons from the Holobiont Hydra. mBio 7(6) e01184-16

Deines P and TCG Bosch (2016) Transitioning from Microbiome Composition to Microbial Community Interactions: The Potential of the Metaorganism Hydra as an Experimental Model. Front. Microbiology, 13 October 2016

Bosch TCG (2016) Emergence of immune system components in Cnidarians. In: Ratcliffe, M.J.H. (Editor in Chief), Encyclopedia of Immunobiology, Vol. 1, pp. 397–406. Oxford: Academic Press.

  Gilson E, Bosch TCG (2016) Understanding why we age and how: Evolutionary biology meets different model organisms and multi-level omics: Meeting report on “Comparative Biology of Aging,” Roscoff, October 12-16, 2015. Bioessays. 2016 Apr 27. doi: 10.1002/bies.201600049

Theis KR, NM Dheilly, J Klassen, RM Brucker, TCG Bosch, JF Cryan,  SF Gilbert, CJ Goodnight, JSapp, P Vandenkoornhuyse, I Zilber-Rosenberg, E Rosenberg, SR Bordenstein (2016) Getting the Hologenome Concept Right: An Eco-Evolutionary Framework for Hosts and Their Microbiomes. mSystems, 1(2):e00028-16. doi:10.1128/mSystems.00028-16.
Publication highlighted in F1000 prime

Bosch TCG and D Miller (2016): The Holobiont Imperative: Perspectives from Early Emerging Animals.  Springer New York. Now available for preorder on amazon.

Gilbert SF, TCG Bosch, C Ledón-Rettig (2015) Eco-Evo-Devo: developmental symbiosis and developmental plasticity as evolutionary agents. Nature Reviews Genetics 16(10):611-22.

Mortzfeld B, S Urbanski, AM Reitzel, S Künzel, U Technau, S Fraune (2015) Response of bacterial colonization in Nematostella vectensis to development, environment and biogeography. Environ. Microbiol., 2015 Jun 1. doi: 10.1111/1462-2920.12926.

Schwentner M and TCG Bosch (2015) Revisiting the age, evolutionary history and species level diversity of the genus Hydra (Cnidaria: Hydrozoa). Mol Phylogenet Evol. 91:41-55.

Li X-Y, C Pietschke, S Fraune, PM Altrock, TCG Bosch and A Traulsen (2015) Which games are growing bacterial populations playing? J. Royal Society Interface, 17 June 2015.DOI: 10.1098/rsif.2015.0121.

  Bosch TCG, JA Grasis & T Lachnit (2015) Microbial ecology in Hydra: Why viruses matter. J Microbiol 53(3):193-200.

Flachsbart F & TCG Bosch (2014) (in German) FoxO und die Alterung sterblicher und unsterblicher Organismen. BIOspektrum 20, 747-749. DOI 10.1007/s12268-014-0513-3 .

Fraune S, F Anton-Erxleben, R Augustin, S Franzenburg, M Knop, Katja Schröder, D Willoweit-Ohl, and TCG Bosch (2014) Bacteria-bacteria interactions within the microbiota of the ancestral metazoan Hydra contribute to fungal resistance. ISME J, 2014 Dec 16. doi: 10.1038/ismej.2014.239. [Epub ahead of print]

Grasis JA, Lachnit T, Anton-Erxleben F, Lim YW, Schmieder R, Fraune S, Franzenburg S, Insua S, Machado G, Haynes M, Little M, Kimble R, Rosenstiel P, Rohwer FL, Bosch TCG (2014) Species-specific viromes in the ancestral holobiont hydra. PLoS One 9(10):e109952.

Bosch TCG, M Adamska, R Augustin, T Domazet-Loso, S Foret, S Fraune, N Funayama, J Grasis, M Hamada, M Hatta, B Hobmayer, K Kawai, A Klimovich, M Manuel, C Shinzato, U Technau, S Yum, and DJ Miller (2014). How do environmental factors influence life cycles and development? An experimental framework for early-diverging metazoans. Bioessays 2014 36(12):1185-94.

The article is accompanied by a 8 min video clip. The video is hosted on Wiley-Blackwell’s Life Sciences You Tube channel

You Tube channel

Bosch TCG (2014) Rethinking the role of immunity: lessons from Hydra. Trends in Immunology 35 (2014), pp. 495-502 DOI 10.1016/j.it.2014.07.008

Domazet-Lošo T, A Klimovich, B Anokhin, F Anton-Erxleben, M Hamm, C Lange, and TCG Bosch (2014) Naturally occurring tumors in the basal metazoan Hydra.  Nature Communications 5, Article number: 4222 doi:10.1038/ncomms5222 Published 24 June 2014. Supplementary Information

Fuchs B, W Wang, S Graspeuntner, Y Li, S Insua, EM Herbst, P Dirksen, AM Böhm, G Hemmrich, F Sommer, T Domazet-Loso, U Klostermeier, F Anton-Erxleben, P Rosenstiel, TCG Bosch, and K Khalturin (2014) Regulation of polyp to jellyfish transition in Aurelia aurita. Current Biology, Current Biology 24, 1–11, February 3, 2014 ª2014 Elsevier Ltd All rights reserved http://dx.doi.org/10.1016/j.cub.2013.12.003 See also “Science” News See also Dispatch R159 from Current Biology

Franzenburg S, J Walter, S Künzel, JF Baines, TCG Bosch, S Fraune (2013) Distinct antimicrobial tissue activity shapes host species-specific bacterial associations. Proc Natl Acad Sci USA, 110(39):E3730-8

Boehm AM, P Rosenstiel, and TCG Bosch (2013) Stem cells and aging from a quasi-immortal point of view. BioEssays Vol 35, Issue 11, 35(11):994-1003

Gehrke S, B Brueckner, A Schepky, J Klein, A Iwen, TCG Bosch, H Wenck, M Winnefeld, S Hagemann (2013) Epigenetic Regulation of Depot-Specific Gene Expression in Adipose Tissue. PLoS ONE 8(12): e82516. doi:10.1371/journal.pone.0082516

 Bosch Thomas C.G. (2013) Cnidarian-Microbe Interactions and the Origin of Innate Immunity in Metazoans. Ann Rev Microbiol Vol 67, 499-518

Franzenburg S, S Fraune, P. M. Altrock, S. Künzel, J. F. Baines, A. Traulsen, T.C.G. Bosch (2013) Bacterial colonization of Hydra hatchlings follows a robust temporal pattern.  ISME J. 2013 Apr;7(4):781-90. The article has been selected for Faculty 1000 – F1000Prime. It was recommended as being of special significance in its field.

 McFall-Ngai M, M Hadfield, T Bosch, H Carey, T Domazet-Loso, A Douglas, N Dubilier, G Eberl, T Fukami, S Gilbert, U Hentschel, N King, S Kjelleberg, A Knoll, N Kremer, S Mazmanian, J Metcalf, K Nealson, N Pierce, J Rawls, A Reid, E Ruby, M Rumpho, J Sanders, D Tautz, and J Wernegreen (2013). Animals in a bacterial world, a new imperative for the life sciences. Proc Natl Acad Sci U S A. 2013 Feb 26;110(9):3229-36.

 Nebel A, Bosch TCG (2012) Evolution of human longevity: lessons from Hydra (Editorial). Aging 4(11):730-731

 Bosch TCG (2012) Bakterien – eher Partner als Feinde; das Immunsystem im Metaorganismus. Biologie in unserer Zeit. Volume 42, Issue 5, pages 302–309, Oktober 2012
 Boehm AM, G Hemmrich, K Khalturin, M Puchert, F Anton-Erxleben, J Wittlieb, UC Klostermeier, P Rosenstiel, H-H Oberg, and TCG Bosch (2012) FoxO is a critical regulator of stem cell maintenance and immortality in Hydra. Proc Natl Acad Sci USA, 109(48):19697-702 

 Fraune S and TCG Bosch (2012) Host-symbiont interactions: why Cnidaria matter.Cell News 3/2012:14-21

 Franzenburg S, S Fraune, S Künzel, JF Baines, T Domazet-Lošo, TCG Bosch (2012) MyD88 deficient Hydra reveal ancient function of TLR-signaling in sensing bacterial colonizers. Proc Natl Acad Sci USA 109 (47): 19374-9

 Bosch TCG (2012) Rethinking the origin of multicellularity: Where do epithelia come from? “(Comment on DOI 10.1002/bies.201100187)”. BioEssays 34(10):826-7

 Fraune J, M Alsheimer, J-N Volff, K Busch, S Fraune, TCG Bosch, R Benavente (2012) Hydra meiosis reveals unexpected conservation of structural synaptonemal complex proteins across metazoans. Proc Natl Acad Sci USA, 109(41):16588-93

 Bosch TCG (2012) What Hydra has to say about the role and origin of symbiotic interactions. Biological Bulletin, 223: 78-84 

 Hemmrich G, K Khalturin, AM Boehm, M Puchert, F Anton-Erxleben, J Wittlieb, UC Klostermeier, P Rosenstiel, HH Oberg, T Domazet-Lošo, T Sugimoto, H Niwa, and TCG Bosch (2012) Molecular signatures of the three stem cell lineages in Hydra and the emergence of stem cell function at the base of multicellularity. Mol. Biol. Evol., doi:10.1093/molbev/mss13 

 Bosch TCG (2012) Understanding complex host-microbe interactions in Hydra. Gut Microbes 3:4, 1-7

 Sommer F, S Awazu, F Anton-Erxleben, D Jiang, AV Klimovich, BV Klimovich, MP Samoilovich, Y Satou, M Kruss, C Gelhaus, U Kurn, TCG Bosch and K Khalturin (2012) Blood system formation in the urochordate Ciona intestinalis requires the variable receptor vCRL1 Mol Biol Evol. 2012 May 3. [Epub ahead of print] PMID: 22513285 [PubMed – as supplied by publisher]

 Boehm AM and TCG Bosch (2012) Migration of multipotent interstitial stem cells in Hydra. Zoology, 2012 Aug 27. [Epub ahead of print] PMID: 22951272 [PubMed – as supplied by publisher]  ScienceDirect

 Brönneke S, B Brückner, N Peters, TCG Bosch, F Stäb, H Wenck, S Hagemann, and M Winnefeld (2012) DNA methylation regulates lineage-specifying genes in the human vascular system. Angiogenesis 15 (2) 317-329

 Augustin R, Fraune S, Franzenburg S, Bosch TCG (2012) Where simplicity meets complexity: hydra, a model for host-microbe interactions. Adv Exp Med Biol. 2012;710:71-81. Review.

 Fraune Sebastian, Sören Franzenburg, René Augustin und Thomas C. G. Bosch (2011) Das Prinzip Metaorganismus. BIOSPEKTRUM Volume 17, Number 6, 634-636

 Forêt S, Seneca F, de Jong D, Bieller A, Hemmrich G, Augustin R, Hayward DC, Ball EE, Bosch TC Agata K, Hassel M, Miller DJ. (2011) Phylogenomics reveals an anomalous distribution of USP genes in metazoans. Mol Biol Evol. 28(1):153-61

 Fraune S, R Augustin, TCG Bosch (2011) Embryo protection in contemporary immunology: Why bacteria matter. Communicative & Integrative (4):369-72

 Bosch TCG and M McFall-Ngai (2011) Metaorganisms as the new frontier. Zoology 114 (2011) 185–190

 Lange C, G Hemmrich, UC Klostermeier, JA López-Quintero, DJ Miller, T Rahn, Y Weiss, TCG Bosch, and P Rosenstiel (2011) Defining the origins of the NOD-like receptor system at the base of animal evolution. Mol Biol Evol 2011 28: 1687-1702

Wittlieb J, K Khalturin, TCG Bosch (2010) Transgene Hydra als vielseitiges Modellsystem in “EvoDevo”. Biospektrum 10/2, 186-188.This article was subsequently also included in textbook „Zellbiologie und Mikrobiologie“, Springer Spektrum-Buchpublikation ( Ed. Dieter Jahn), 2012.

 Anokhin B., G. Hemmrich-Stanisak , T.C.G. Bosch (2010) Karyotyping and single-gene detection using fluorescence in situ hybridization on chromosomes of Hydra magnipapillata (Cnidaria). Comparative Cytogenetics 4(2),97-110

 Fraune S, R Augustin, F Anton-Erxleben, Jörg Wittlieb, C Gelhaus, V. B. Klimovich,M. P. Samoilovich, and T.C.G. Bosch (2010) In an early branching metazoan, bacterial colonization of the embryo is controlled by maternal antimicrobial peptides Proc. Natl. Acad. Sci. USA , 107,18067-18072 Featured as “Research Highlights” in Nature Immunology (2010) 11, 1083

 Augustin R and Bosch TCG (2010) Cnidarian Immunity: A Tale of Two Barriers K. Söderhäll (ed.) Invertebrate Immunity Landes Bioscience and Springer Science+Business Media, Review.

 Fraune S and TCG Bosch (2010) Why bacteria matter in animal development and evolution. Bioessays 32: 571–580

 Bosch TCG, Anton-Erxleben F, Hemmrich G, Khalturin K (2010)The Hydra polyp: Nothing but an active stem cell community.Dev Growth Differ. 52(1): 15-25

 Chapman JA , EF Kirkness, O Simakov, … K Khalturin, G Hemmrich, A Franke, R Augustin, S Fraune, … JC Venter, U Technau,B Hobmayer, TCG Bosch, TW Holstein, T Fujisawa, HR Bode, CN David, DS Rokhsar, RE Steele (2010)The dynamic genome of Hydra. Nature 464 (7288): 592-596

 Gee L,  J Hartig, L Law, J Wittlieb, K Khalturin, TCG Bosch, and HR Bode (2010) Beta-catenin plays a central role in setting up the head organizer in hydra. Dev. Biol., 340 (2010) 116–124

 Augustin R, Fraune S, and TCG Bosch (2010) How Hydra senses and destroys microbes. Seminars in Immunology 22(2010), 54-58.