2017

paperAndrea P. Murillo-Rincon, Alexander Klimovich, Eileen Pemöller, Jan Taubenheim, Benedikt Mortzfeld, René Augustin, Thomas C. G. Bosch (2017) Spontaneous body contractions are modulated by the microbiome of Hydra. Scientific Reports, in press

paperPietschke C, C Treitz, S Forêt, A Schultze, S Künzel, A Tholey, T Bosch, S Fraune (2017) Host modification of a bacterial quorum sensing signal induces a phenotypic switch in bacterial symbionts. Proc Natl Acad Sci US, 114(40):E8488-E8497

paperAugustin R, K Schröder, AP Murillo Rincón, S Fraune, F Anton-Erxleben, E-M Herbst, J Wittlieb1, M Schwentner, J Grötzinger, TM Wassenaar, TCG Bosch (2017) A secreted antibacterial neuropeptide shapes the microbiome in Hydra. Nature Comm., 8(1):69

ReviewMortzfeld B and TCG Bosch (2017) Eco-Ageing: stem cells and microbes are controlled by ageing antagonist FoxO. Current Opinion in Microbiology, 38:181-187

ReviewDeines P, T Lachnit and TCG Bosch (2017) Competing forces maintain the Hydra metaorganism. Immunol Reviews, 279(1):123-136

ReviewBosch T.C.G., A. Klimovich, T. Domazet-Lošo, S. Gründer, T.W. Holstein, G. Jékely, D.J. Miller, A.P. Murillo-Rincon, F. Rentzsch, G.S. Richards, K. Schröder, U. Technau, R. Yuste (2017) Back to the Basics: Cnidarians Start to Fire. Trends in Neurosciences, 40(2): 92 – 105 pdficon

Trends in Neurosciences, Volume 40

2016

Review Augustin R and TCG Bosch (2016) Revisiting the Cutaneous Epithelium: Insights from a Nontraditional Model System. Akt Dermatol 42: 414-420 pdficon

Review Schröder K and TCG Bosch (2016) The Origin of Mucosal Immunity: Lessons from the Holobiont Hydra. mBio 7(6) e01184-16 pdficon

Review Deines P and TCG Bosch (2016) Transitioning from Microbiome Composition to Microbial Community Interactions: The Potential of the Metaorganism Hydra as an Experimental Model. Front. Microbiology, 13 October 2016 pdficon

Review Bosch TCG (2016) Emergence of immune system components in Cnidarians. In: Ratcliffe, M.J.H. (Editor in Chief), Encyclopedia of Immunobiology, Vol. 1, pp. 397–406. Oxford: Academic Press. pdficon

Review  Gilson E, Bosch TCG (2016) Understanding why we age and how: Evolutionary biology meets different model organisms and multi-level omics: Meeting report on “Comparative Biology of Aging,” Roscoff, October 12-16, 2015. Bioessays. 2016 Apr 27. doi: 10.1002/bies.201600049 pdficon

paper

Theis KR, NM Dheilly, J Klassen, RM Brucker, TCG Bosch, JF Cryan,  SF Gilbert, CJ Goodnight, JSapp, P Vandenkoornhuyse, I Zilber-Rosenberg, E Rosenberg, SR Bordenstein (2016) Getting the Hologenome Concept Right: An Eco-Evolutionary Framework for Hosts and Their Microbiomes. mSystems, 1(2):e00028-16. doi:10.1128/mSystems.00028-16. pdficon
Publication highlighted in F1000 prime

book Bosch TCG and D Miller (2016): The Holobiont Imperative: Perspectives from Early Emerging Animals.  Springer New York. Now available for preorder on amazon.Buch

2015

Review Gilbert SF, TCG Bosch, C Ledón-Rettig (2015) Eco-Evo-Devo: developmental symbiosis and developmental plasticity as evolutionary agents. Nature Reviews Genetics 16(10):611-22. pdficon

paper Mortzfeld B, S Urbanski, AM Reitzel, S Künzel, U Technau, S Fraune (2015) Response of bacterial colonization in Nematostella vectensis to development, environment and biogeography. Environ. Microbiol., 2015 Jun 1. doi: 10.1111/1462-2920.12926.

paper Schwentner M and TCG Bosch (2015) Revisiting the age, evolutionary history and species level diversity of the genus Hydra (Cnidaria: Hydrozoa). Mol Phylogenet Evol. 91:41-55.pdficon

paper Li X-Y, C Pietschke, S Fraune, PM Altrock, TCG Bosch and A Traulsen (2015) Which games are growing bacterial populations playing? J. Royal Society Interface, .

Review  Bosch TCG, JA Grasis & T Lachnit (2015) Microbial ecology in Hydra: Why viruses matter. J Microbiol 53(3):193-200.pdficon

2014

Review Flachsbart F & TCG Bosch (2014) (in German) FoxO und die Alterung sterblicher und unsterblicher Organismen. BIOspektrum 20, 747-749. DOI 10.1007/s12268-014-0513-3 .pdficon

paper Fraune S, F Anton-Erxleben, R Augustin, S Franzenburg, M Knop, Katja Schröder, D Willoweit-Ohl, and TCG Bosch (2014) Bacteria-bacteria interactions within the microbiota of the ancestral metazoan Hydra contribute to fungal resistance. ISME J, 2014 Dec 16. doi: 10.1038/ismej.2014.239. [Epub ahead of print] pdficon

paper Grasis JA, Lachnit T, Anton-Erxleben F, Lim YW, Schmieder R, Fraune S, Franzenburg S, Insua S, Machado G, Haynes M, Little M, Kimble R, Rosenstiel P, Rohwer FL, Bosch TCG (2014) Species-specific viromes in the ancestral holobiont hydra. PLoS One 9(10):e109952.pdficon

paper Bosch TCG, M Adamska, R Augustin, T Domazet-Loso, S Foret, S Fraune, N Funayama, J Grasis, M Hamada, M Hatta, B Hobmayer, K Kawai, A Klimovich, M Manuel, C Shinzato, U Technau, S Yum, and DJ Miller (2014). How do environmental factors influence life cycles and development? An experimental framework for early-diverging metazoans. Bioessays 2014 36(12):1185-94.pdficon

The article is accompanied by a 8 min video clip. The video is hosted on Wiley-Blackwell’s Life Sciences You Tube channel

You Tube channel

ReviewBosch TCG (2014) Rethinking the role of immunity: lessons from Hydra. Trends in Immunology 35 (2014), pp. 495-502 DOI 10.1016/j.it.2014.07.008pdficon

paper Domazet-Lošo T, A Klimovich, B Anokhin, F Anton-Erxleben, M Hamm, C Lange, and TCG Bosch (2014) Naturally occurring tumors in the basal metazoan Hydra.  Nature Communications 5, Article number: 4222 doi:10.1038/ncomms5222 Published 24 June 2014. pdficonSupplementary Information pdficon

paper Fuchs B, W Wang, S Graspeuntner, Y Li, S Insua, EM Herbst, P Dirksen, AM Böhm, G Hemmrich, F Sommer, T Domazet-Loso, U Klostermeier, F Anton-Erxleben, P Rosenstiel, TCG Bosch, and K Khalturin (2014) Regulation of polyp to jellyfish transition in Aurelia aurita. Current Biology, Current Biology 24, 1–11, February 3, 2014 ª2014 Elsevier Ltd All rights reserved http://dx.doi.org/10.1016/j.cub.2013.12.003 pdficon See also Science” News See also Dispatch R159 from Current Biology

2013

paper Franzenburg S, J Walter, S Künzel, JF Baines, TCG Bosch, S Fraune (2013) Distinct antimicrobial tissue activity shapes host species-specific bacterial associations. Proc Natl Acad Sci USA, 110(39):E3730-8 pdficon

Review Boehm AM, P Rosenstiel, and TCG Bosch (2013) Stem cells and aging from a quasi-immortal point of view. BioEssays Vol 35, Issue 11, 35(11):994-1003 pdficon

paper Gehrke S, B Brueckner, A Schepky, J Klein, A Iwen, TCG Bosch, H Wenck, M Winnefeld, S Hagemann (2013) Epigenetic Regulation of Depot-Specific Gene Expression in Adipose Tissue. PLoS ONE 8(12): e82516. doi:10.1371/journal.pone.0082516

Review Bosch Thomas C.G. (2013) Cnidarian-Microbe Interactions and the Origin of Innate Immunity in Metazoans. Ann Rev Microbiol Vol 67, 499-518 pdficon

paper Franzenburg S, S Fraune, P. M. Altrock, S. Künzel, J. F. Baines, A. Traulsen, T.C.G. Bosch (2013) Bacterial colonization of Hydra hatchlings follows a robust temporal pattern.  ISME J. 2013 Apr;7(4):781-90. The article has been selected for Faculty 1000 – F1000Prime. It was recommended as being of special significance in its field.pdficon

paper McFall-Ngai M, M Hadfield, T Bosch, H Carey, T Domazet-Loso, A Douglas, N Dubilier, G Eberl, T Fukami, S Gilbert, U Hentschel, N King, S Kjelleberg, A Knoll, N Kremer, S Mazmanian, J Metcalf, K Nealson, N Pierce, J Rawls, A Reid, E Ruby, M Rumpho, J Sanders, D Tautz, and J Wernegreen (2013). Animals in a bacterial world, a new imperative for the life sciences. Proc Natl Acad Sci U S A. 2013 Feb 26;110(9):3229-36. pdficon

2012

Review Nebel A, Bosch TCG (2012) Evolution of human longevity: lessons from Hydra (Editorial). Aging 4(11):730-731 pdficon

Review Bosch TCG (2012) Bakterien – eher Partner als Feinde; das Immunsystem im Metaorganismus. Biologie in unserer Zeit. Volume 42, Issue 5, pages 302–309, Oktober 2012
paper Boehm AM, G Hemmrich, K Khalturin, M Puchert, F Anton-Erxleben, J Wittlieb, UC Klostermeier, P Rosenstiel, H-H Oberg, and TCG Bosch (2012) FoxO is a critical regulator of stem cell maintenance and immortality in Hydra. Proc Natl Acad Sci USA, 109(48):19697-702  pdficon

Review Fraune S and TCG Bosch (2012) Host-symbiont interactions: why Cnidaria matter.Cell News 3/2012:14-21

paper Franzenburg S, S Fraune, S Künzel, JF Baines, T Domazet-Lošo, TCG Bosch (2012) MyD88 deficient Hydra reveal ancient function of TLR-signaling in sensing bacterial colonizers. Proc Natl Acad Sci USA 109 (47): 19374-9 pdficon

Review Bosch TCG (2012) Rethinking the origin of multicellularity: Where do epithelia come from? “(Comment on DOI 10.1002/bies.201100187)”. BioEssays 34(10):826-7

paper Fraune J, M Alsheimer, J-N Volff, K Busch, S Fraune, TCG Bosch, R Benavente (2012) Hydra meiosis reveals unexpected conservation of structural synaptonemal complex proteins across metazoans. Proc Natl Acad Sci USA, 109(41):16588-93

Review Bosch TCG (2012) What Hydra has to say about the role and origin of symbiotic interactions. Biological Bulletin, 223: 78-84  pdficon

paper Hemmrich G, K Khalturin, AM Boehm, M Puchert, F Anton-Erxleben, J Wittlieb, UC Klostermeier, P Rosenstiel, HH Oberg, T Domazet-Lošo, T Sugimoto, H Niwa, and TCG Bosch (2012) Molecular signatures of the three stem cell lineages in Hydra and the emergence of stem cell function at the base of multicellularity. Mol. Biol. Evol., doi:10.1093/molbev/mss13  pdficon

Review Bosch TCG (2012) Understanding complex host-microbe interactions in Hydra. Gut Microbes 3:4, 1-7 pdficon

paper Sommer F, S Awazu, F Anton-Erxleben, D Jiang, AV Klimovich, BV Klimovich, MP Samoilovich, Y Satou, M Kruss, C Gelhaus, U Kurn, TCG Bosch and K Khalturin (2012) Blood system formation in the urochordate Ciona intestinalis requires the variable receptor vCRL1 Mol Biol Evol. 2012 May 3. [Epub ahead of print] PMID: 22513285 [PubMed – as supplied by publisher] pdficon

paper Boehm AM and TCG Bosch (2012) Migration of multipotent interstitial stem cells in Hydra. Zoology, 2012 Aug 27. [Epub ahead of print] PMID: 22951272 [PubMed – as supplied by publisher]  ScienceDirect pdficon

paper Brönneke S, B Brückner, N Peters, TCG Bosch, F Stäb, H Wenck, S Hagemann, and M Winnefeld (2012) DNA methylation regulates lineage-specifying genes in the human vascular system. Angiogenesis 15 (2) 317-329

Review Augustin R, Fraune S, Franzenburg S, Bosch TCG (2012) Where simplicity meets complexity: hydra, a model for host-microbe interactions. Adv Exp Med Biol. 2012;710:71-81. Review.

2011

Review Fraune Sebastian, Sören Franzenburg, René Augustin und Thomas C. G. Bosch (2011) Das Prinzip Metaorganismus. BIOSPEKTRUM Volume 17, Number 6, 634-636

paper Forêt S, Seneca F, de Jong D, Bieller A, Hemmrich G, Augustin R, Hayward DC, Ball EE, Bosch TC Agata K, Hassel M, Miller DJ. (2011) Phylogenomics reveals an anomalous distribution of USP genes in metazoans. Mol Biol Evol. 28(1):153-61

Review Fraune S, R Augustin, TCG Bosch (2011) Embryo protection in contemporary immunology: Why bacteria matter. Communicative & Integrative (4):369-72 pdficon

Review Bosch TCG and M McFall-Ngai (2011) Metaorganisms as the new frontier. Zoology 114 (2011) 185–190 pdficon

paper Lange C, G Hemmrich, UC Klostermeier, JA López-Quintero, DJ Miller, T Rahn, Y Weiss, TCG Bosch, and P Rosenstiel (2011) Defining the origins of the NOD-like receptor system at the base of animal evolution. Mol Biol Evol 2011 28: 1687-1702 pdficon

2010

paper Wittlieb J, K Khalturin, TCG Bosch (2010) Transgene Hydra als vielseitiges Modellsystem in “EvoDevo”. Biospektrum 10/2, 186-188.This article was subsequently also included in textbook „Zellbiologie und Mikrobiologie“, Springer Spektrum-Buchpublikation ( Ed. Dieter Jahn), 2012.

paper Anokhin B., G. Hemmrich-Stanisak , T.C.G. Bosch (2010) Karyotyping and single-gene detection using fluorescence in situ hybridization on chromosomes of Hydra magnipapillata (Cnidaria). Comparative Cytogenetics 4(2),97-110

paper Fraune S, R Augustin, F Anton-Erxleben, Jörg Wittlieb, C Gelhaus, V. B. Klimovich,M. P. Samoilovich, and T.C.G. Bosch (2010) In an early branching metazoan, bacterial colonization of the embryo is controlled by maternal antimicrobial peptides Proc. Natl. Acad. Sci. USA , 107,18067-18072 pdficon Featured as “Research Highlights” in Nature Immunology (2010) 11, 1083
pdficon

Review Augustin R and Bosch TCG (2010) Cnidarian Immunity: A Tale of Two Barriers K. Söderhäll (ed.) Invertebrate Immunity Landes Bioscience and Springer Science+Business Media, Review.

Review Fraune S and TCG Bosch (2010) Why bacteria matter in animal development and evolution. Bioessays 32: 571–580 pdficon

paper Bosch TCG, Anton-Erxleben F, Hemmrich G, Khalturin K (2010)The Hydra polyp: Nothing but an active stem cell community.Dev Growth Differ. 52(1): 15-25 pdficon

paper Chapman JA , EF Kirkness, O Simakov, … K Khalturin, G Hemmrich, A Franke, R Augustin, S Fraune, … JC Venter, U Technau,B Hobmayer, TCG Bosch, TW Holstein, T Fujisawa, HR Bode, CN David, DS Rokhsar, RE Steele (2010)The dynamic genome of Hydra. Nature 464 (7288): 592-596 pdficon

paper Gee L,  J Hartig, L Law, J Wittlieb, K Khalturin, TCG Bosch, and HR Bode (2010) Beta-catenin plays a central role in setting up the head organizer in hydra. Dev. Biol., 340 (2010) 116–124 pdficon

Review Augustin R, Fraune S, and TCG Bosch (2010) How Hydra senses and destroys microbes. Seminars in Immunology 22(2010), 54-58.pdficon

2009

paper Augustin R, Anton-Erxleben F, Jungnickel S, Hemmrich G, Spudy B, Podschun R, and TCG Bosch (2009) Activity of the novel peptide Arminin against multiresistant human pathogens shows the considerable potential of phylogenetically ancient organisms as drug sources. Antimicrobial Agents and Chemotherapy 53(12), 5245-5250.

Review Fraune S, Augustin R, and TCG Bosch (2009) Exploring host-microbe interactions in hydra. Microbe 4(10), 457-462.

Review Khalturin K, Hemmrich G, Fraune S, Augustin R, and TCG Bosch (2009) More than just orphans: are taxonomically restricted genes important in evolution? Trends in Genetics, 25(9), 404-413

paper Fraune S, Abe Y, and TCG Bosch (2009) Disturbing epithelial homeostasis in the metazoan Hydra leads to drastic changes in associated microbiota. Environ Microbiol. 11(9):2361-9.

Review Bosch TCG (2009) Evolutionäres Vermächtnis: Stammzellen in Hydra. Biologie In Unserer Zeit 2/2009 (39), 114 – 122. DOI:10.1002/biuz.200910390

Review Rosenstiel P, Philipp E, Schreiber S and TCG Bosch (2009) Evolution and Function of Innate Immune Receptors – Insights from Marine Invertebrates. J Innate Immun 1:291 – 300

paper Takahashi T, Koizumi O, Hayakawa E, Minobe S, Suetsugu R, Kobayakawa Y, Bosch TC, David CN, Fujisawa T. (2009) Further characterization of the PW peptide family that inhibits neuron differentiation in Hydra. Dev Genes Evol, 219(3), 119-129

paper Augustin R, Siebert S, and TCG Bosch (2009) Identification of a kazal-type serine protease inhibitor with potent anti-staphylococcal activity as part of hydra’s innate immune system. Dev Comp Immunology, 33(7), 830-837

Review Bosch Thomas C. G. (2009) Hydra and the evolution of stem cells. BioEssays, 31(4), 478-486

paper Milde S, Hemmrich G, Anton-Erxleben F, Khalturin K, Wittlieb J, and TCG Bosch (2009) Characterization of taxonomically-restricted genes in a phylum-restricted cell type. Genome Biol. 10(1):R8

paper Siebert S, Anton-Erxleben F, Kiko R, Kramer M (2009) Sympagohydra tuuli (Cnidaria, Hydrozoa): first report from sea ice of the central Arctic Ocean and insights into histology, reproduction and locomotion. Mar Biol, 156(4), 541-554.

paper Jung S, Dingley AJ, Augustin R, Anton-Erxleben F, Stanisak M, Gelhaus C, Gutsmann T, Hammer MU, Podschun R, Leippe M, TCG Bosch and Grötzinger J (2009) Hydramacin-1: Structure and antibacterial activity of a protein from the basal metazoan hydra. J Biol Chem, 284(3), 1896-905.

paper Bosch TCG, R Augustin, F Anton-Erxleben, S Fraune, G Hemmrich, H Zill, P Rosenstiel, G Jacobs, S Schreiber, M Leippe, M Stanisak, J Grötzinger, S Jung, R Podschun, J Bartels, J Harder, J-M Schröder (2009). Uncovering the Evolutionary History of Innate Immunity: the Simple Metazoan Hydra Uses Epithelial Cells for Host Defence. Dev Comp Immunol. 33 (2009), 559-569