Paper      Book or Book Chapter     Review

Book: TCG Bosch & M Hadfield (Eds.) Cellular Dialogues in the Holobiont. CRC Press, Tayler & Francis Group, Boca Raton, London, New York, July 28, 2020 ISBN  978-0-367-22881-1 (hbk); ISBN 978-0-429-27737-5 (ebk)  cover

Hadfield MC and TCG Bosch (2020) Cellular dialogues between hosts and microbial symbionts – Generalities emerging. In: Cellular Dialogues in the Holobiont. pp 287-290. CRC Press (Eds. TCG Bosch & M Hadfield) ISBN  978-0-367-22881-1 (hbk); ISBN 978-0-429-27737-5 (ebk)

Book Chapter:   Bathia J and TCG Bosch (2020) Symbiotic interactions in the holobiont Hydra. In: Cellular Dialogues in the Holobiont. pp 65-78  CRC Press (Eds. TCG Bosch & M Hadfield) ISBN  978-0-367-22881-1 (hbk); ISBN 978-0-429-27737-5 (ebk)

Book Chapter:   Bosch TCG (2020) Stem cells in an holobiont: lessons from Hydra ) In: Deferring development: setting aside cells for future use in development and evolution (Eds Cory Bishop and Brian K. Hall). CRC Press. Evolutionary Cell Biology Series. ISBN 9781138334281

Lousada MB, Lachnit T, Edelkamp J, Rouillé T, Ajdic D, Uchida Y, Di Nardo A, Bosch TCG, Paus R (2020) Exploring the human hair follicle microbiome. Br J Dermatol. 2020 Aug 6. doi: 10.1111/bjd.19461. Online ahead of print.

Mason B, Cooke I, Moya A, Augustin R, Lin M-F, Satoh N, Bosch TCG, Bourne DG, Hayward DC, Andrade N, Forêt S, Ying H, Ball EE, Miller DJ (2020) AmAMP1 from Acropora millepora and damicornin de 1 fine a family of coral-specific antimicrobial peptides related to the Shk toxins of sea anemones. Dev Comp Immun., in press

Deines P, Hammerschmidt K, TCG Bosch (2020) Exploring the niche concept in a simple metaorganism. Frontiers in Microbiology 11:1942. doi: 10.3389/fmicb.2020.01942. eCollection 2020.

Taubenheim J, Willoweit-Ohl D, Knop M, Franzenburg S, He J, Bosch TCG, Fraune S (2020) Bacteria- and temperature-regulated peptides modulate beta-catenin signalling in Hydra. Proc Natl Acad Sci USA,

Deines P, Hammerschmidt K, Bosch TCG (2020) Microbial Species Coexistence Depends on the Host Environment. mBio. 11(4):e00807-20. doi: 10.1128/mBio.00807-20

Klimovich A, Giacomello S, Björklund Å, Faure L, Kaucka M, Giez C, Murillo-Rincon AP, Matt A-S, Willoweit-Ohl D, Crupi G, de Anda J, Wong  GCL, D’Amato M, Adameyko I, Bosch TCG (2020) Prototypical pacemaker neurons interact with the resident microbiota. Proc Natl Acad Sci US, July 9 2020 https://doi.org/10.1073/pnas.1920469117 

See also the commentary by Yuuki Obata and Vassilis Pachnis from The Francis Crick Institute:
Yuuki Obata and Vassilis Pachnis (2020) Linking neurons to immunity: Lessons from Hydra. Proc Natl Academy Sci US, doi/10.1073/pnas.2011637117 

Rathje K, Mortzfeld B, Hoeppner MP, Taubenheim J, Bosch TCG, Klimovich A (2020) Dynamic interactions within the host-associated microbiota cause tumor formation in the basal metazoan Hydra. PLoS Pathog. 16(3):e1008375.

Finlay BB,  Blaser MJ, Bosch TCG, Dominguez-Bello MG, Elinav E, McFall-Ngai M, Melby MK, Muehlmann SR,  Sansonetti PJ (2020) Are non-communicable diseases communicable? Science, 17 January 2020 • VOL 367 ISSUE 6475  +

Bosch TCG (2020) The model zoologist: how should we think about animals, model animals, and non-model model animals? (Editorial) Zoology Volume 138, February 2020, 125749

López-Quintero JA, Torres GG, Neme R,  Bosch TCG (2019) Boundary maintenance in the ancestral metazoan Hydra depends on histone acetylation. Developmental Biology, https://doi.org/10.1016/j.ydbio.2019.11.006

 Rausch P, Rühlmann M, … Bosch TCG, Baines JF (2019) Comparative analysis of amplicon and metagenomic sequencing methods reveals key features in the evolution of animal metaorganisms. Microbiome, in press

Mortzfeld BM, Taubenheim J, Klimovich AV, Fraune S, Rosenstiel P, Bosch TCG (2019). Temperature and insulin signaling regulate body size in Hydra by the Wnt and TGF-beta pathways. Nature Comm.

Johnke J, Fraune S, Bosch TCG, Hentschel U, Schulenburg H (2019) Bdellovibrio and Like Organisms are Predictors of Microbiome Diversity in distinct Host Groups. Microbial Ecology, Microb Ecol. 2019 Jun 11. doi: 10.1007/s00248-019-01395-7

Klimovich A, Wittlieb J, Bosch TCG (2019) Transgenesis in Hydra to characterize gene function and visualize cell behaviour. Nature Protocol, https://rdcu.be/bFvBI

Sieber M, Pita L, Weiland-Bräuer N, Dirksen P, Wang J, Mortzfeld B, Franzenburg S, Schmitz RA, Baines JF, Fraune S, Hentschel U, Schulenburg H, Bosch TCG, and Traulsen A (2019): Neutrality in the  Metaorganism. PLoS Biol, 2019 Jun 19;17(6):e3000298

Finlay B, Pettersson S, Melby M, Bosch TCG (2019) The microbiome mediates environmental effects on ageing. BioEssays, e1800257. doi: 10.1002/bies.201800257

Lachnit T, Bosch TCG, Deines P (2019): Exposure of the host-associated microbiome to nutrient-rich conditions may lead to dysbiosis and disease development – an evolutionary perspective. mBio 10:e00355-19.

Bosch TCG (2019) Squid genomes in a bacterial world. Proc Natl Acad Sci USA. 116(8):2799-2801. doi: 10.1073/pnas.1822166116. (Comment on “Symbiotic organs shaped by distinct modes of genome evolution in cephalopods”, Proc Natl Acad Sci U S A. 2019)

Jaspers C, Fraune S, Consortium of Australian Academy of Science Boden Research Conference Participants, Arnold AE, Miller DJ, Bosch TCG, Voolstra CR (2019) Resolving structure and function of metaorganisms through a holistic framework 2 combining reductionist and integrative approaches. Zoology, 133:81-87. doi: 10.1016/j.zool.2019.02.007

Bosch TCG, Guillemin K, McFall-Ngai M (2019) Evolutionary “experiments” in symbiosis: the study of model animals provides insights into the mechanisms underlying diversity of host-microbe interactions”. BioEssays, e1800256

Rees T, Bosch TCG, AE Douglas (2018) The Microbiome and the Human: A Reply to Parke et al. PLoS Biol 16(9): e2006974. doi.org/10.1371/journal.pbio.2006974

von Frieling J, Fink C, Hamm J, Klischies K, Forster M, Bosch TCG, Roeder T, Rosenstiel P, Sommer F (2018). Grow with the challenge – microbial effects on epithelial proliferation, carcinogenesis and cancer therapy. Front Microbiol., 9:2020. doi: 10.3389/fmicb.2018.02020

Klimovich, A. V. and Bosch, T. C. (2018), Rethinking the Role of the Nervous System: Lessons From the Hydra Holobiont. BioEssays. . doi:10.1002/bies.201800060 

Hamada M, Schröder K, Bathia J, Kürn U, Fraune S, Khalturina M, Khalturin K, Shinzato  C, Satoh N, Bosch TCG (2018) Metabolic co-dependence drives the evolutionarily ancient Hydra-Chlorella symbiosis. eLife 2018;7:e35122 https://doi.org/10.7554/eLife.35122 

Klimovich A, Rehm A, Wittlieb J, Herbst E, Benavente R, Bosch TC, . Non-senescent Hydra tolerates severe disturbances in the nuclear lamina. Aging (Albany NY). 2018; 10:951-972. https://doi.org/10.18632/aging.101440

Rees T, TCG Bosch, AE Douglas (2018) How the Microbiome Challenges our Concept of Self. PLoS Biol. 16(2):e2005358

Bang, C, Dagan T, Deines P, Dubilier N, Duschl WJ, Fraune S, Hentschel U, Hirt H, Hülter N, Lachnit T, Picazo D, Pita L, Pogoreutz C, Radecker N, Saad MM, Schmitz RA, Schulenburg H, Voolstra CR, Weiland-Brauer N, Ziegler M, Bosch TCG (2018). Metaorganisms in extreme environments: do microbes play a role in organismal adaptation? Zoology 127 (2018), 1-19

Wein T, Dagan T, Fraune S, TCG Bosch, Burkhard T, Reusch H, NF Hülter (2018) Carrying capacity and colonization dynamics of the Hydra host habitat. Front. Microbiol, 9:443.

Mortzfeld BM, Taubenheim J, Fraune S, Klimovich AV, Bosch TCG (2018). Stem cell transcription factor FoxO controls microbiome resilience in Hydra. Front Microbiol., 9:629.

Li X-Y, Lachnit T, Fraune S, Bosch TCG, Traulsen A, Sieber M (2017) Temperate phages as self-replicating weapons in bacterial competition. J. R. Soc. Interface 14:20170563 

Murillo-Rincon AP, Klimovich A, Pemöller E, Taubenheim J, Mortzfeld B, Augustin R, Bosch TCG (2017) Spontaneous body contractions are modulated by the microbiome of Hydra. Sci Rep. 7(1):15937 

Pietschke C, C Treitz, S Forêt, A Schultze, S Künzel, A Tholey, T Bosch, S Fraune (2017) Host modification of a bacterial quorum sensing signal induces a phenotypic switch in bacterial symbionts. Proc Natl Acad Sci US, 114(40):E8488-E8497

Augustin R, K Schröder, AP Murillo Rincón, S Fraune, F Anton-Erxleben, E-M Herbst, J Wittlieb1, M Schwentner, J Grötzinger, TM Wassenaar, TCG Bosch (2017) A secreted antibacterial neuropeptide shapes the microbiome in Hydra. Nature Comm., 8(1):69

Mortzfeld B and TCG Bosch (2017) Eco-Ageing: stem cells and microbes are controlled by ageing antagonist FoxO. Current Opinion in Microbiology, 38:181-187

Deines P, T Lachnit and TCG Bosch (2017) Competing forces maintain the Hydra metaorganism. Immunol Reviews, 279(1):123-136

Bosch T.C.G., A. Klimovich, T. Domazet-Lošo, S. Gründer, T.W. Holstein, G. Jékely, D.J. Miller, A.P. Murillo-Rincon, F. Rentzsch, G.S. Richards, K. Schröder, U. Technau, R. Yuste (2017) Back to the Basics: Cnidarians Start to Fire. Trends in Neurosciences, 40(2): 92 – 105

Augustin R and TCG Bosch (2016) Revisiting the Cutaneous Epithelium: Insights from a Nontraditional Model System. Akt Dermatol 42: 414-420

Schröder K and TCG Bosch (2016) The Origin of Mucosal Immunity: Lessons from the Holobiont Hydra. mBio 7(6) e01184-16

Deines P and TCG Bosch (2016) Transitioning from Microbiome Composition to Microbial Community Interactions: The Potential of the Metaorganism Hydra as an Experimental Model. Front. Microbiology, 13 October 2016

Bosch TCG (2016) Emergence of immune system components in Cnidarians. In: Ratcliffe, M.J.H. (Editor in Chief), Encyclopedia of Immunobiology, Vol. 1, pp. 397–406. Oxford: Academic Press.

  Gilson E, Bosch TCG (2016) Understanding why we age and how: Evolutionary biology meets different model organisms and multi-level omics: Meeting report on “Comparative Biology of Aging,” Roscoff, October 12-16, 2015. Bioessays. 2016 Apr 27. doi: 10.1002/bies.201600049

Theis KR, NM Dheilly, J Klassen, RM Brucker, TCG Bosch, JF Cryan,  SF Gilbert, CJ Goodnight, JSapp, P Vandenkoornhuyse, I Zilber-Rosenberg, E Rosenberg, SR Bordenstein (2016) Getting the Hologenome Concept Right: An Eco-Evolutionary Framework for Hosts and Their Microbiomes. mSystems, 1(2):e00028-16. doi:10.1128/mSystems.00028-16.
Publication highlighted in F1000 prime

Bosch TCG and D Miller (2016): The Holobiont Imperative: Perspectives from Early Emerging Animals.  Springer New York. Now available for preorder on amazon.

Gilbert SF, TCG Bosch, C Ledón-Rettig (2015) Eco-Evo-Devo: developmental symbiosis and developmental plasticity as evolutionary agents. Nature Reviews Genetics 16(10):611-22.

Mortzfeld B, S Urbanski, AM Reitzel, S Künzel, U Technau, S Fraune (2015) Response of bacterial colonization in Nematostella vectensis to development, environment and biogeography. Environ. Microbiol., 2015 Jun 1. doi: 10.1111/1462-2920.12926.

Schwentner M and TCG Bosch (2015) Revisiting the age, evolutionary history and species level diversity of the genus Hydra (Cnidaria: Hydrozoa). Mol Phylogenet Evol. 91:41-55.

Li X-Y, C Pietschke, S Fraune, PM Altrock, TCG Bosch and A Traulsen (2015) Which games are growing bacterial populations playing? J. Royal Society Interface, 17 June 2015.DOI: 10.1098/rsif.2015.0121.

  Bosch TCG, JA Grasis & T Lachnit (2015) Microbial ecology in Hydra: Why viruses matter. J Microbiol 53(3):193-200.

Flachsbart F & TCG Bosch (2014) (in German) FoxO und die Alterung sterblicher und unsterblicher Organismen. BIOspektrum 20, 747-749. DOI 10.1007/s12268-014-0513-3 .

Fraune S, F Anton-Erxleben, R Augustin, S Franzenburg, M Knop, Katja Schröder, D Willoweit-Ohl, and TCG Bosch (2014) Bacteria-bacteria interactions within the microbiota of the ancestral metazoan Hydra contribute to fungal resistance. ISME J, 2014 Dec 16. doi: 10.1038/ismej.2014.239. [Epub ahead of print]

Grasis JA, Lachnit T, Anton-Erxleben F, Lim YW, Schmieder R, Fraune S, Franzenburg S, Insua S, Machado G, Haynes M, Little M, Kimble R, Rosenstiel P, Rohwer FL, Bosch TCG (2014) Species-specific viromes in the ancestral holobiont hydra. PLoS One 9(10):e109952.

Bosch TCG, M Adamska, R Augustin, T Domazet-Loso, S Foret, S Fraune, N Funayama, J Grasis, M Hamada, M Hatta, B Hobmayer, K Kawai, A Klimovich, M Manuel, C Shinzato, U Technau, S Yum, and DJ Miller (2014). How do environmental factors influence life cycles and development? An experimental framework for early-diverging metazoans. Bioessays 2014 36(12):1185-94.

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Bosch TCG (2014) Rethinking the role of immunity: lessons from Hydra. Trends in Immunology 35 (2014), pp. 495-502 DOI 10.1016/j.it.2014.07.008

Domazet-Lošo T, A Klimovich, B Anokhin, F Anton-Erxleben, M Hamm, C Lange, and TCG Bosch (2014) Naturally occurring tumors in the basal metazoan Hydra.  Nature Communications 5, Article number: 4222 doi:10.1038/ncomms5222 Published 24 June 2014. Supplementary Information

Fuchs B, W Wang, S Graspeuntner, Y Li, S Insua, EM Herbst, P Dirksen, AM Böhm, G Hemmrich, F Sommer, T Domazet-Loso, U Klostermeier, F Anton-Erxleben, P Rosenstiel, TCG Bosch, and K Khalturin (2014) Regulation of polyp to jellyfish transition in Aurelia aurita. Current Biology, Current Biology 24, 1–11, February 3, 2014 ª2014 Elsevier Ltd All rights reserved http://dx.doi.org/10.1016/j.cub.2013.12.003 See also “Science” News See also Dispatch R159 from Current Biology

Franzenburg S, J Walter, S Künzel, JF Baines, TCG Bosch, S Fraune (2013) Distinct antimicrobial tissue activity shapes host species-specific bacterial associations. Proc Natl Acad Sci USA, 110(39):E3730-8

Boehm AM, P Rosenstiel, and TCG Bosch (2013) Stem cells and aging from a quasi-immortal point of view. BioEssays Vol 35, Issue 11, 35(11):994-1003

Gehrke S, B Brueckner, A Schepky, J Klein, A Iwen, TCG Bosch, H Wenck, M Winnefeld, S Hagemann (2013) Epigenetic Regulation of Depot-Specific Gene Expression in Adipose Tissue. PLoS ONE 8(12): e82516. doi:10.1371/journal.pone.0082516

 Bosch Thomas C.G. (2013) Cnidarian-Microbe Interactions and the Origin of Innate Immunity in Metazoans. Ann Rev Microbiol Vol 67, 499-518

Franzenburg S, S Fraune, P. M. Altrock, S. Künzel, J. F. Baines, A. Traulsen, T.C.G. Bosch (2013) Bacterial colonization of Hydra hatchlings follows a robust temporal pattern.  ISME J. 2013 Apr;7(4):781-90. The article has been selected for Faculty 1000 – F1000Prime. It was recommended as being of special significance in its field.

 McFall-Ngai M, M Hadfield, T Bosch, H Carey, T Domazet-Loso, A Douglas, N Dubilier, G Eberl, T Fukami, S Gilbert, U Hentschel, N King, S Kjelleberg, A Knoll, N Kremer, S Mazmanian, J Metcalf, K Nealson, N Pierce, J Rawls, A Reid, E Ruby, M Rumpho, J Sanders, D Tautz, and J Wernegreen (2013). Animals in a bacterial world, a new imperative for the life sciences. Proc Natl Acad Sci U S A. 2013 Feb 26;110(9):3229-36.

 Nebel A, Bosch TCG (2012) Evolution of human longevity: lessons from Hydra (Editorial). Aging 4(11):730-731

 Bosch TCG (2012) Bakterien – eher Partner als Feinde; das Immunsystem im Metaorganismus. Biologie in unserer Zeit. Volume 42, Issue 5, pages 302–309, Oktober 2012
 Boehm AM, G Hemmrich, K Khalturin, M Puchert, F Anton-Erxleben, J Wittlieb, UC Klostermeier, P Rosenstiel, H-H Oberg, and TCG Bosch (2012) FoxO is a critical regulator of stem cell maintenance and immortality in Hydra. Proc Natl Acad Sci USA, 109(48):19697-702 

 Fraune S and TCG Bosch (2012) Host-symbiont interactions: why Cnidaria matter.Cell News 3/2012:14-21

 Franzenburg S, S Fraune, S Künzel, JF Baines, T Domazet-Lošo, TCG Bosch (2012) MyD88 deficient Hydra reveal ancient function of TLR-signaling in sensing bacterial colonizers. Proc Natl Acad Sci USA 109 (47): 19374-9

 Bosch TCG (2012) Rethinking the origin of multicellularity: Where do epithelia come from? “(Comment on DOI 10.1002/bies.201100187)”. BioEssays 34(10):826-7

 Fraune J, M Alsheimer, J-N Volff, K Busch, S Fraune, TCG Bosch, R Benavente (2012) Hydra meiosis reveals unexpected conservation of structural synaptonemal complex proteins across metazoans. Proc Natl Acad Sci USA, 109(41):16588-93

 Bosch TCG (2012) What Hydra has to say about the role and origin of symbiotic interactions. Biological Bulletin, 223: 78-84 

 Hemmrich G, K Khalturin, AM Boehm, M Puchert, F Anton-Erxleben, J Wittlieb, UC Klostermeier, P Rosenstiel, HH Oberg, T Domazet-Lošo, T Sugimoto, H Niwa, and TCG Bosch (2012) Molecular signatures of the three stem cell lineages in Hydra and the emergence of stem cell function at the base of multicellularity. Mol. Biol. Evol., doi:10.1093/molbev/mss13 

 Bosch TCG (2012) Understanding complex host-microbe interactions in Hydra. Gut Microbes 3:4, 1-7

 Sommer F, S Awazu, F Anton-Erxleben, D Jiang, AV Klimovich, BV Klimovich, MP Samoilovich, Y Satou, M Kruss, C Gelhaus, U Kurn, TCG Bosch and K Khalturin (2012) Blood system formation in the urochordate Ciona intestinalis requires the variable receptor vCRL1 Mol Biol Evol. 2012 May 3. [Epub ahead of print] PMID: 22513285 [PubMed – as supplied by publisher]

 Boehm AM and TCG Bosch (2012) Migration of multipotent interstitial stem cells in Hydra. Zoology, 2012 Aug 27. [Epub ahead of print] PMID: 22951272 [PubMed – as supplied by publisher]  ScienceDirect

 Brönneke S, B Brückner, N Peters, TCG Bosch, F Stäb, H Wenck, S Hagemann, and M Winnefeld (2012) DNA methylation regulates lineage-specifying genes in the human vascular system. Angiogenesis 15 (2) 317-329

 Augustin R, Fraune S, Franzenburg S, Bosch TCG (2012) Where simplicity meets complexity: hydra, a model for host-microbe interactions. Adv Exp Med Biol. 2012;710:71-81. Review.