paper F Anton-Erxleben, A Thomas, J Wittlieb, S Fraune, and TCG Bosch (2008). Plasticity of epithelial cell shape in response to upstream signals: a whole-organism study using transgenic Hydra. Zoology, 112(3): 185-194

paper K Khalturin, F Anton-Erxleben, S Sassmann, J Wittlieb, G Hemmrich, and TCG Bosch (2008). A novel gene family controls species-specific morphological traits in Hydra. PLoS Biology 6 (11): e278 see also the  “Tentacles test tenets of evolution” commentary in “The Scientist” Featured as “Research highlights” in Nature Reviews Genetics January 2009 Volume 10 Number 1

book Bosch TCG (2008) The Path Less Explored: Innate Immune Reactions in Cnidarians. In: H. Heine (ed.), Innate Immunity of Plants, Animals, and Humans. Nucleic Acids and Molecular Biology 21. Springer-Verlag Berlin Heidelberg. Review.

book Khalturin K, U Kürn, and TCG Bosch (2008) Immune Reactions in the Vertebrates’ Closest Relatives, the Urochordates. In: H. Heine (ed.), Innate Immunity of Plants, Animals, and Humans. Nucleic Acids and Molecular Biology 21. Springer-Verlag Berlin Heidelberg. Review.

Review Hemmrich G and Bosch TCG (2008) Compagen, a comparative genomics platform for early branching metazoan animals, reveals early origins of genes regulating stem cell differentiation. BioEssays 20(10), 1010-1018

paper Schwarz RS, Bosch TCG and Cadavid LF (2008) Evolution of polydom-like molecules: Identification and characterization of cnidarian polydom (Cnpolydom) in the basal metazoan Hydractinia Dev Comp Immun. 32, 1192-1210

book Bosch Thomas C. G. (Ed.) (2008) “Stem Cells: From Hydra to Man”. 192 pages. Springer Netherlands (2008) ISBN-10: 1402082738; ISBN-13: 978-1402082733


paper Siebert S, Anton-Erxleben F and Bosch TCG (2007) Cell type complexity in the basal metazoan Hydra is maintained by both stem cell based mechanisms and transdifferentiation. Dev. Biol. 313: 13-24

Review Hemmrich G, Miller DJ and Bosch TCG (2007) The evolution of immunity – A low life perspective. Trends Immunol., 28(10), 449-454

paper Fraune S and Bosch TCG (2007) Long-term maintenance of species-specific bacterial microbiota in the basal metazoan Hydra. Proc. Natl. Acad. Sci. USA 104, 13146-13151

paper Khalturin K, Anton-Erxleben F, Milde S, Plötz C, Wittlieb J, Hemmrich G and Bosch TCG (2007) Transgenic stem cells in Hydra reveal an early evolutionary origin for key elements controlling self-renewal and differentiation. Dev. Biol. 309: 32-44

paper Hemmrich G, Anokhin B, Zacharias H and Bosch TCG (2007) Molecular phylogenetics in Hydra, a classical model in evolutionary developmental biology. Mol. Phylogenet. Evol. 44:281-290

paper Kürn U, Sommer F, Bosch TCG and K Khalturin (2007) In the urochordate Ciona intestinalis zona pellucida domain proteins vary among individuals. Dev. Comp. Immun. 31: 1242-1254

paper Miller DJ, Hemmrich G, Ball EE, Hayward DC, Khalturin K, Funayama N, Agata K and Bosch TCG (2007) The innate immune repertoire in Cnidaria – ancestral complexity and stochastic gene loss. Genome Biol. 8(4):R59

book Bosch TCG (2007) Symmetry breaking in stem cells of the basal metazoan Hydra. In: Asymmetric cell division Series: Progress in Molecular and Subcellular Biology (Ed. Macieira-Coelho). pp. 61-78, Springer, Heidelberg.

Review Bosch TCG (2007) Why polyps regenerate and we don´t: towards a cellular and molecular framework for Hydra regeneration. Dev. Biol. 303:421-433



Review Khalturin K and Bosch TCG (2006) Self / nonself discrimination at the basis of chordate evolution: limits on molecular conservation. Curr. Opin. Immunol. 18:1-6

paper Kürn U, Sommer F, Hemmrich G, Bosch TCG and Khalturin K (2006) Allorecognition in urochordates: identification of a highly variable complement receptor-like protein expressed in follicle cells of Ciona. Dev. Comp. Immun. 31(4):360-71

paper Augustin R, Franke A, Khalturin K, Kiko R, Siebert S, Hemmrich G and Bosch TCG (2006) Dickkopf related genes are components of the positional value gradient in Hydra. Dev. Biol. 296: 62-70

paper Wittlieb J, Khalturin K, Lohmann JU, Anton-Erxleben F and Bosch TCG (2006) Transgenic Hydra allow in vivo tracking of individual stem cells during morphogenesis. Proc. Natl. Acad. Sci. USA 103;16: 6208-6211 see also the commentary “Trembley´s polyps go transgenic” in PNAS 103 (17): 6415-6416

paper Genikhovich G, Kürn U, Hemmrich G and Bosch TCG (2006) Discovery of genes expressed in Hydra embryogenesis. Dev. Biol. 15;289(2): 466-81

paper Thomsen S and Bosch TCG (2006) Foot differentiation and genomic plasticity in Hydra: lessons from the PPOD gene family. Dev. Genes and Evol. 216(2):57-68


paper Siebert S, Thomsen S, Reimer MM, Bosch TCG (2005) Control of foot differentiation in Hydra: phylogenetic footprinting indicates interaction of head, bud and foot patterning systems. Mech. Dev. 122(9):998-1007

paper Habetha M and Bosch TCG (2005) Symbiotic Hydra express a plant-like peroxidase gene during oogenesis. J. Exp. Biol. 208:2157-2164

paper Khalturin K, Kürn U, Pinnow N and Bosch TCG (2005) Towards a molecular code for individuality in the absence of MHC: screening for individually variable genes in the urochordate Ciona intestinalis. Dev. Comp. Immunol. 29(9):759-773


paper Khalturin K, Pancer Z, Cooper MD and Bosch TCG (2004) Recognition strategies in the innate immune system of ancestral chordates. Mol. Immunol. 41(11):1077-1087

Review Bosch TCG (2004) Control of asymmetric cell divisions: will cnidarians provide an answer? BioEssays 26(9):929-931

paper Zacharias H, Anokhin B, Khalturin K and Bosch TCG (2004) Genome sizes and chromosomes in the basal metazoan Hydra Zoology 107(3): 219–227

paper Thomsen S, Till A, Beetz C, Wittlieb J, Khalturin K and Bosch TCG (2004) Control of foot diffenrentiation in Hydra: in vitro evidence that the NK-2 homeobox factor CnK-2 autoregulates its own expression and uses pedibin as target gene. Mech. Dev. 121(2): 195-204

paper Fedders H, Augustin R and Bosch TCG (2004) A Dickkopf-3 related gene is expressed in differentiating nematocytes in the basal metazoan Hydra. Dev. Genes Evol. 214(2):72-80


paper Fröbius AC, Genikhovich G, Kürn U, Anton-Erxleben F and Bosch TCG (2003) Expression of developmental genes during early embryogenesis of Hydra. Dev. Genes Evol. 213(9):445-455

paper Kuznetsov SG and Bosch TCG (2003) Self/nonself recognition in Cnidaria: contact to allogeneic tissue does not result in elimination of nonself cells in Hydra vulgaris. Zoology 106(2):109-116

paper Habetha M, Anton-Erxleben F, Neumann K and Bosch TCG (2003) The Hydra viridis / Chlorella symbiosis. (I) Growth and sexual differentiation in polyps without symbionts. Zoology 106(2):101-108

paper Khalturin K, Becker M, Rinkevich B and Bosch TCG (2003) Urochordates and the origin of natural killer cells: identification of a CD94 / NKR-P1 related receptor in blood cells in Botryllus. Proc. Natl. Acad. Sci. USA 21;100(2): 622-6272 See also: Science, Editors` Choice,Vol.299 Journal of Cell Biology, Research Roundup, Vol.160

Review Bosch TCG (2003) Ancient signals: peptides and the interpretation of positional information in ancestral metazoans. Comp. Biochem. Physiol. Part B: Biochemistry and Molecular Biology 136, 185-196

paper Kasahara S and Bosch TCG (2003) Enhanced antibacterial activity in Hydra polyps lacking nerve cells. Dev. Comp. Immunol. 27: 79-166

paper Khalthurin K, Kuznetsov S and Bosch TCG (2003) PCR Fluorescence Differential Display. PCR Protocols, 2nd edition (eds. J Bartlett & D Stirling) Humana Press, Totowa, New Jersey.


paper Kuznetsov SG, Anton-Erxleben F and Bosch TCG (2002) Epithelial interactions in Hydra: apoptosis in interspecies grafts is induced by detachment from the extracellular matrix. J. Exp. Biol. 205(24):3809-3817

paper Bosch TCG, Augustin R, Gellner K, Khalturin K and Lohmann JU (2002) In vivo electroporation for genetic manipulations of whole Hydra polyps. Differentiation 70(4-5):140-147

Review Bosch TCG and Khalturin K (2002) Patterning and cell differentiation in Hydra: novel genes and the limits to conservation. Canadian Journal of Zoology 80:1670-1677


paper Kuznetsov S, Lyanguzowa M and Bosch TCG (2001) Role of epithelial cells and programmed cell death in Hydra spermatogenesis. Zoology 104(1):25-31

Review Bosch TCG (2001) Neue Tricks von alten Tieren: wie bildet Hydra einen Kopf? BIOforum, 1-2/2001, 57-59.

Review Bosch TCG and Fujisawa T (2001) Polyps, peptides and patterning. BioEssays 23(5) 420-427


paper M Cardenas, Y Fabila, S Yum, J Cerbon, F Böhmer, R Wetzker, T Fujisawa, TCG Bosch, and LM Salgado (2000) Selective protein kinase inhibitors block head-specific differentiation in hydra. Cellular Signalling 12, 649-658

paper Lohmann Jan U. and TCG Bosch (2000) The novel peptide HEADY specifies apical fate in a simple, radially symmetric metazoan. Genes and Development, 14 (21) 2771-2777 Comments in Nature Reviews Genetics (2000) 1: 16; Scientific American Online, The Scientist (2000) 14(23): 24; Bild der Wissenschaft, u.a.

paper Venturelli CR., S Kuznetsov, LM. Salgado, TCG Bosch (2000) An IQGAP-related gene is activated during tentacle formation in the simple metazoan Hydra. Dev Gene Evol 210 (2000) 8/9, 458-463

paper Takahashi T, O Koizumi, Y Ariura, A Romanovitch, TCG Bosch, Y Kobayakawa, S Mohri, HR Bode, S Yum, M Hatta and T Fujisawa (2000) A novel neuropeptide, Hym-355, positively regulates neuron differentiation in Hydra. Development, 127 (5): 997-1005


paper Lohmann Jan U., Ingrid Endl, and TCG Bosch (1999) Silencing of developmental genes in Hydra. Developmental Biology, 214: 211-214

paper Kumpfmüller G, V Rybakine, T Takahashi, T Fujisawa and TCG Bosch (1999) Identification of an astacin matrix metalloprotease as target gene for Hydra foot activator peptides. Development, Genes and Evolution, 209, 601-607.

paper Endl I, J Lohmann and TCG Bosch (1999) Head specific gene expression in Hydra: Complexity of DNA / protein interactions at the promoter of ks1 is inversely correlated to the head activation potential. Proc. Natl. Acad. Sci. USA 96, 1445-1450.

paper Tom M, J Douek, I Yankelevich, TCG Bosch, and B Rinkevich (1999) Molecular characterization of the first heat shock protein 70 from a reef coral. Biochem. Biophys. Res. Commun., 262, 103-108

paper Reinhardt B, U Frank, K Gellner, JU Lohmann, and TCG Bosch (1999) High-resolution, fluorescence-based differential display on a DNA sequencer followed by band excision. BioTechniques, 27 (2) 268-270.

Review Bosch TCG (1999) Neue Wege in der Genanalyse. Laborpraxis 10, 20-22.

book Bosch TCG and J Lohmann (1999) Non-radioactive differential display of messenger RNA. In: Methods in Molecular Biology The Nucleic Acid Protocols Handbook (ed. Ralph Rapley) Humana Press, Totowa, New Jersey.

book Lohmann J and TCG Bosch (1999) Non-radioactive differential display and isolation of mRNA In Expression Genetics: Differential Display (eds A Pardee and M McClelland). Eaton Publishing.