The Bosch lab uncovers links between microbiome and essential tissue contractions for healthy bowel function

The contractions of the body are triggered by nerve cells (in green); Bacteria (in red) intervene in the regulatory mechanism of the pacemaker cells underlying this process.
Figure: Christoph Giez, dr. Alexander Klimovich

Spontaneous contractions of the digestive tract play an important role in the vast majority of organisms in order to ensure a healthy intestinal function. From simple invertebrates to humans, there are consistently similar movement patterns that transport and mix the contents of the intestine through the rhythmic contraction of the muscles. These contractions of the intestine are indispensable for the digestive process and are referred to in science as peristalsis. In various diseases of the digestive tract, for example, serious inflammatory bowel disease in humans, there are disorders of natural peristalsis. So far, little is explored by which factors these contractions are controlled.

Ph.D. student Andrea Murillo together with postdoc Alexander Klimovich and other members of the Bosch lab could prove for the first time that bacterial colonization plays an important role in peristalsis in the freshwater polyp Hydra. The observation that microorganisms within the gut can affect essential pacemaker functions in peristalsis are  published in the journal “Scientific Reports”.

2019

paper Rausch P, Rühlmann M, … Bosch TCG, Baines JF (2019) Comparative analysis of amplicon and metagenomic sequencing methods reveals key features in the evolution of animal metaorganisms. Microbiome, in press

paperMortzfeld BM, Taubenheim J, Klimovich AV, Fraune S, Rosenstiel P, Bosch TCG (2019). Temperature and insulin signaling regulate body size in Hydra by the Wnt and TGF-beta pathways. Nature Comm. pdficon

paperJohnke J, Fraune S, Bosch TCG, Hentschel U, Schulenburg H (2019) Bdellovibrio and Like Organisms are Predictors of Microbiome Diversity in distinct Host Groups. Microbial Ecology, Microb Ecol. 2019 Jun 11. doi: 10.1007/s00248-019-01395-7 pdficon

paperKlimovich A, Wittlieb J, Bosch TCG (2019) Transgenesis in Hydra to characterize gene function and visualize cell behaviour. Nature Protocol, https://rdcu.be/bFvBI pdficon

paperSieber M, Pita L, Weiland-Bräuer N, Dirksen P, Wang J, Mortzfeld B, Franzenburg S, Schmitz RA, Baines JF, Fraune S, Hentschel U, Schulenburg H, Bosch TCG, and Traulsen A (2019): Neutrality in the  Metaorganism. PLoS Biol, 2019 Jun 19;17(6):e3000298pdficon

ReviewFinlay B, Pettersson S, Melby M, Bosch TCG (2019) The microbiome mediates environmental effects on ageing. BioEssays, e1800257. doi: 10.1002/bies.201800257 pdficon

paper Lachnit T, Bosch TCG, Deines P (2019): Exposure of the host-associated microbiome to nutrient-rich conditions may lead to dysbiosis and disease development – an evolutionary perspective. mBio 10:e00355-19. pdficon

ReviewBosch TCG (2019) Squid genomes in a bacterial world. Proc Natl Acad Sci USA. 116(8):2799-2801. doi: 10.1073/pnas.1822166116. (Comment on “Symbiotic organs shaped by distinct modes of genome evolution in cephalopods”, Proc Natl Acad Sci U S A. 2019) pdficon

paperJaspers C, Fraune S, Consortium of Australian Academy of Science Boden Research Conference Participants, Arnold AE, Miller DJ, Bosch TCG, Voolstra CR (2019) Resolving structure and function of metaorganisms through a holistic framework 2 combining reductionist and integrative approaches. Zoology, 133:81-87. doi: 10.1016/j.zool.2019.02.007pdficon

ReviewBosch TCG, Guillemin K, McFall-Ngai M (2019) Evolutionary “experiments” in symbiosis: the study of model animals provides insights into the mechanisms underlying diversity of host-microbe interactions”. BioEssays, e1800256 pdficon

2018

Review Rees T, Bosch TCG, AE Douglas (2018) The Microbiome and the Human: A Reply to Parke et al. PLoS Biol 16(9): e2006974. doi.org/10.1371/journal.pbio.2006974 pdficon

Review von Frieling J, Fink C, Hamm J, Klischies K, Forster M, Bosch TCG, Roeder T, Rosenstiel P, Sommer F (2018). Grow with the challenge – microbial effects on epithelial proliferation, carcinogenesis and cancer therapy. Front Microbiol., 9:2020. doi: 10.3389/fmicb.2018.02020 pdficon

Review Klimovich, A. V. and Bosch, T. C. (2018), Rethinking the Role of the Nervous System: Lessons From the Hydra Holobiont. BioEssays. . doi:10.1002/bies.201800060 pdficon

 

paper Hamada M, Schröder K, Bathia J, Kürn U, Fraune S, Khalturina M, Khalturin K, Shinzato  C, Satoh N, Bosch TCG (2018) Metabolic co-dependence drives the evolutionarily ancient Hydra-Chlorella symbiosis. eLife 2018;7:e35122 https://doi.org/10.7554/eLife.35122  pdficon

paper Klimovich A, Rehm A, Wittlieb J, Herbst E, Benavente R, Bosch TC, . Non-senescent Hydra tolerates severe disturbances in the nuclear lamina. Aging (Albany NY). 2018; 10:951-972. https://doi.org/10.18632/aging.101440 pdficon

Review Rees T, TCG Bosch, AE Douglas (2018) How the Microbiome Challenges our Concept of Self. PLoS Biol. 16(2):e2005358 pdficon

Review Bang, C, Dagan T, Deines P, Dubilier N, Duschl WJ, Fraune S, Hentschel U, Hirt H, Hülter N, Lachnit T, Picazo D, Pita L, Pogoreutz C, Radecker N, Saad MM, Schmitz RA, Schulenburg H, Voolstra CR, Weiland-Brauer N, Ziegler M, Bosch TCG (2018). Metaorganisms in extreme environments: do microbes play a role in organismal adaptation? Zoology 127 (2018), 1-19pdficon

paper Wein T, Dagan T, Fraune S, TCG Bosch, Burkhard T, Reusch H, NF Hülter (2018) Carrying capacity and colonization dynamics of the Hydra host habitat. Front. Microbiol, 9:443.

paper Mortzfeld BM, Taubenheim J, Fraune S, Klimovich AV, Bosch TCG (2018). Stem cell transcription factor FoxO controls microbiome resilience in Hydra. Front Microbiol., 9:629.pdficon