Postdoc Sebastian Fraune was offered a position as tenured professor at the University of Düsseldorf. Congratulation, Sebastian!
Spontaneous contractions of the digestive tract play an important role in the vast majority of organisms in order to ensure a healthy intestinal function. From simple invertebrates to humans, there are consistently similar movement patterns that transport and mix the contents of the intestine through the rhythmic contraction of the muscles. These contractions of the intestine are indispensable for the digestive process and are referred to in science as peristalsis. In various diseases of the digestive tract, for example, serious inflammatory bowel disease in humans, there are disorders of natural peristalsis. So far, little is explored by which factors these contractions are controlled.
Ph.D. student Andrea Murillo together with postdoc Alexander Klimovich and other members of the Bosch lab could prove for the first time that bacterial colonization plays an important role in peristalsis in the freshwater polyp Hydra. The observation that microorganisms within the gut can affect essential pacemaker functions in peristalsis are published in the journal “Scientific Reports”.
Bosch, TCG (2019) Squid genomes in a bacterial world. Proc Natl Acad Sci USA, Jan 11 2019 doi.org/10.1073/pnas.1822166116 . Commentary on Belkaid et al (2019) Symbiotic organs shaped by distinct modes of genome evolution in cephalopods. PNAS 10.1073/pnas.1817322116
Rees T, Bosch TCG, AE Douglas (2018) The Microbiome and the Human: A Reply to Parke et al. PLoS Biol 16(9): e2006974. doi.org/10.1371/journal.pbio.2006974
von Frieling J, Fink C, Hamm J, Klischies K, Forster M, Bosch TCG, Roeder T, Rosenstiel P, Sommer F (2018). Grow with the challenge – microbial effects on epithelial proliferation, carcinogenesis and cancer therapy. Front Microbiol., in press
Klimovich, A. V. and Bosch, T. C. (2018), Rethinking the Role of the Nervous System: Lessons From the Hydra Holobiont. BioEssays. . doi:10.1002/bies.201800060
Hamada M, Schröder K, Bathia J, Kürn U, Fraune S, Khalturina M, Khalturin K, Shinzato C, Satoh N, Bosch TCG (2018) Metabolic co-dependence drives the evolutionarily ancient Hydra-Chlorella symbiosis. eLife 2018;7:e35122 https://doi.org/10.7554/eLife.35122
Klimovich A, Rehm A, Wittlieb J, Herbst E, Benavente R, Bosch TC, . Non-senescent Hydra tolerates severe disturbances in the nuclear lamina. Aging (Albany NY). 2018; 10:951-972. https://doi.org/10.18632/aging.101440
Bang, C, Dagan T, Deines P, Dubilier N, Duschl WJ, Fraune S, Hentschel U, Hirt H, Hülter N, Lachnit T, Picazo D, Pita L, Pogoreutz C, Radecker N, Saad MM, Schmitz RA, Schulenburg H, Voolstra CR, Weiland-Brauer N, Ziegler M, Bosch TCG (2018). Metaorganisms in extreme environments: do microbes play a role in organismal adaptation? Zoology 127 (2018), 1-19