The Bosch lab uncovers links between microbiome and essential tissue contractions for healthy bowel function

The contractions of the body are triggered by nerve cells (in green); Bacteria (in red) intervene in the regulatory mechanism of the pacemaker cells underlying this process.
Figure: Christoph Giez, dr. Alexander Klimovich

Spontaneous contractions of the digestive tract play an important role in the vast majority of organisms in order to ensure a healthy intestinal function. From simple invertebrates to humans, there are consistently similar movement patterns that transport and mix the contents of the intestine through the rhythmic contraction of the muscles. These contractions of the intestine are indispensable for the digestive process and are referred to in science as peristalsis. In various diseases of the digestive tract, for example, serious inflammatory bowel disease in humans, there are disorders of natural peristalsis. So far, little is explored by which factors these contractions are controlled.

Ph.D. student Andrea Murillo together with postdoc Alexander Klimovich and other members of the Bosch lab could prove for the first time that bacterial colonization plays an important role in peristalsis in the freshwater polyp Hydra. The observation that microorganisms within the gut can affect essential pacemaker functions in peristalsis are  published in the journal “Scientific Reports”.

2019

ReviewKlimovich A, Wittlieb J, Bosch TCG (2019) Transgenesis in Hydra to characterize gene function and visualize cell behaviour. Nature Protocol, in press

paperSieber M, Pita L, Weiland-Bräuer N, Dirksen P, Wang J, Mortzfeld B, Franzenburg S, Schmitz RA, Baines JF, Fraune S, Hentschel U, Schulenburg H, Bosch TCG, and Traulsen A (2019): Neutrality in the  Metaorganism. PLoS Biol, in press

ReviewLachnit T, Bosch TCG, Deines P (2019): Exposure of the host-associated microbiome to nutrient-rich conditions may lead to dysbiosis and disease development – an evolutionary perspective. mBio, in press

ReviewJaspers C, Fraune S, Consortium of Australian Academy of Science Boden Research Conference Participants, Arnold AE, Miller DJ, Bosch TCG, Voolstra CR (2019) Resolving structure and function of metaorganisms through a holistic framework 2 combining reductionist and integrative approaches. Zoology, in press

ReviewFinlay B, Pettersson S, Melby M, Bosch TCG (2019) The microbiome mediates environmental effects on ageing. BioEssays, in press

ReviewBosch TCG, Guillemin K, McFall-Ngai M (2019) Evolutionary “experiments” in symbiosis: the study of model animals provides insights into the mechanisms underlying diversity of host-microbe interactions”. BioEssays, in press

ReviewBosch, TCG (2019) Squid genomes in a bacterial world. Proc Natl Acad Sci USA, Jan 11 2019 doi.org/10.1073/pnas.1822166116  pdficon. Commentary on Belkaid et al (2019) Symbiotic organs shaped by distinct modes of genome evolution in cephalopods. PNAS 10.1073/pnas.1817322116

 

2018

Review Rees T, Bosch TCG, AE Douglas (2018) The Microbiome and the Human: A Reply to Parke et al. PLoS Biol 16(9): e2006974. doi.org/10.1371/journal.pbio.2006974 pdficon

Review von Frieling J, Fink C, Hamm J, Klischies K, Forster M, Bosch TCG, Roeder T, Rosenstiel P, Sommer F (2018). Grow with the challenge – microbial effects on epithelial proliferation, carcinogenesis and cancer therapy. Front Microbiol., in press

Review Klimovich, A. V. and Bosch, T. C. (2018), Rethinking the Role of the Nervous System: Lessons From the Hydra Holobiont. BioEssays. . doi:10.1002/bies.201800060 pdficon

 

paper Hamada M, Schröder K, Bathia J, Kürn U, Fraune S, Khalturina M, Khalturin K, Shinzato  C, Satoh N, Bosch TCG (2018) Metabolic co-dependence drives the evolutionarily ancient Hydra-Chlorella symbiosis. eLife 2018;7:e35122 https://doi.org/10.7554/eLife.35122  pdficon

paper Klimovich A, Rehm A, Wittlieb J, Herbst E, Benavente R, Bosch TC, . Non-senescent Hydra tolerates severe disturbances in the nuclear lamina. Aging (Albany NY). 2018; 10:951-972. https://doi.org/10.18632/aging.101440 pdficon

Review Rees T, TCG Bosch, AE Douglas (2018) How the Microbiome Challenges our Concept of Self. PLoS Biol. 16(2):e2005358 pdficon

Review Bang, C, Dagan T, Deines P, Dubilier N, Duschl WJ, Fraune S, Hentschel U, Hirt H, Hülter N, Lachnit T, Picazo D, Pita L, Pogoreutz C, Radecker N, Saad MM, Schmitz RA, Schulenburg H, Voolstra CR, Weiland-Brauer N, Ziegler M, Bosch TCG (2018). Metaorganisms in extreme environments: do microbes play a role in organismal adaptation? Zoology 127 (2018), 1-19pdficon

paper Wein T, Dagan T, Fraune S, TCG Bosch, Burkhard T, Reusch H, NF Hülter (2018) Carrying capacity and colonization dynamics of the Hydra host habitat. Front. Microbiol, 9:443.

paper Mortzfeld BM, Taubenheim J, Fraune S, Klimovich AV, Bosch TCG (2018). Stem cell transcription factor FoxO controls microbiome resilience in Hydra. Front Microbiol., 9:629.pdficon