Publications

Current Biology    BIOL12    Annual Review of Microbiology    BIOL2        BIOL3    BIOL4    BIOL5    BIOL6        BIOL7    BIOL8    BIOL9      BIOL10        BIOL11    BIOL13    BIOL14      BIOL15        BIOL16Trends in Neurosciences, Volume 40

 

paper Paper    book  Book or Book Chapter    Review Review

2017

Review Bosch T.C.G., A. Klimovich, T. Domazet-Lošo, S. Gründer, T.W. Holstein, G. Jékely, D.J. Miller, A.P. Murillo-Rincon, F. Rentzsch, G.S. Richards, K. Schröder, U. Technau, R. Yuste (2017) Back to the Basics: Cnidarians Start to Fire. Trends in Neurosciences, 40(2): 92 – 105 pdficon

Trends in Neurosciences, Volume 40

2016

Review Augustin R and TCG Bosch (2016) Revisiting the Cutaneous Epithelium: Insights from a Nontraditional Model System. Akt Dermatol 42: 414-420 pdficon

Review Schröder K and TCG Bosch (2016) The Origin of Mucosal Immunity: Lessons from the Holobiont Hydra. mBio 7(6) e01184-16 pdficon

Review Deines P and TCG Bosch (2016) Transitioning from Microbiome Composition to Microbial Community Interactions: The Potential of the Metaorganism Hydra as an Experimental Model. Front. Microbiology, 13 October 2016 pdficon

Review Bosch TCG (2016) Emergence of immune system components in Cnidarians. In: Ratcliffe, M.J.H. (Editor in Chief), Encyclopedia of Immunobiology, Vol. 1, pp. 397–406. Oxford: Academic Press. pdficon

Review  Gilson E, Bosch TCG (2016) Understanding why we age and how: Evolutionary biology meets different model organisms and multi-level omics: Meeting report on “Comparative Biology of Aging,” Roscoff, October 12-16, 2015. Bioessays. 2016 Apr 27. doi: 10.1002/bies.201600049 pdficon

paper

Theis KR, NM Dheilly, J Klassen, RM Brucker, TCG Bosch, JF Cryan,  SF Gilbert, CJ Goodnight, JSapp, P Vandenkoornhuyse, I Zilber-Rosenberg, E Rosenberg, SR Bordenstein (2016) Getting the Hologenome Concept Right: An Eco-Evolutionary Framework for Hosts and Their Microbiomes. mSystems, 1(2):e00028-16. doi:10.1128/mSystems.00028-16. pdficon
Publication highlighted in F1000 prime

book Bosch TCG and D Miller (2016): The Holobiont Imperative: Perspectives from Early Emerging Animals.  Springer New York. Now available for preorder at amazon: www.amazon.com Buch

2015

Review Gilbert SF, TCG Bosch, C Ledón-Rettig (2015) Eco-Evo-Devo: developmental symbiosis and developmental plasticity as evolutionary agents. Nature Reviews Genetics 16(10):611-22. pdficon

paper Mortzfeld B, S Urbanski, AM Reitzel, S Künzel, U Technau, S Fraune (2015) Response of bacterial colonization in Nematostella vectensis to development, environment and biogeography. Environ. Microbiol., 2015 Jun 1. doi: 10.1111/1462-2920.12926.

paper Schwentner M and TCG Bosch (2015) Revisiting the age, evolutionary history and species level diversity of the genus Hydra (Cnidaria: Hydrozoa). Mol Phylogenet Evol. 91:41-55.pdficon

paper Li X-Y, C Pietschke, S Fraune, PM Altrock, TCG Bosch and A Traulsen (2015) Which games are growing bacterial populations playing? J. Royal Society Interface, .

Review  Bosch TCG, JA Grasis & T Lachnit (2015) Microbial ecology in Hydra: Why viruses matter. J Microbiol 53(3):193-200.pdficon

2014

Review Flachsbart F & TCG Bosch (2014) (in German) FoxO und die Alterung sterblicher und unsterblicher Organismen. BIOspektrum 20, 747-749. DOI 10.1007/s12268-014-0513-3 .pdficon

paper Fraune S, F Anton-Erxleben, R Augustin, S Franzenburg, M Knop, Katja Schröder, D Willoweit-Ohl, and TCG Bosch (2014) Bacteria-bacteria interactions within the microbiota of the ancestral metazoan Hydra contribute to fungal resistance. ISME J, 2014 Dec 16. doi: 10.1038/ismej.2014.239. [Epub ahead of print] pdficon

 

paper Grasis JA, Lachnit T, Anton-Erxleben F, Lim YW, Schmieder R, Fraune S, Franzenburg S, Insua S, Machado G, Haynes M, Little M, Kimble R, Rosenstiel P, Rohwer FL, Bosch TCG (2014) Species-specific viromes in the ancestral holobiont hydra. PLoS One 9(10):e109952.pdficon

paper Bosch TCG, M Adamska, R Augustin, T Domazet-Loso, S Foret, S Fraune, N Funayama, J Grasis, M Hamada, M Hatta, B Hobmayer, K Kawai, A Klimovich, M Manuel, C Shinzato, U Technau, S Yum, and DJ Miller (2014). How do environmental factors influence life cycles and development? An experimental framework for early-diverging metazoans. Bioessays 2014 36(12):1185-94.pdficon

The article is accompanied by a 8 min video clip. The video is hosted on Wiley-Blackwell’s Life Sciences You Tube channel

You Tube channel

Review

Bosch TCG (2014) Rethinking the role of immunity: lessons from Hydra. Trends in Immunology 35 (2014), pp. 495-502 DOI 10.1016/j.it.2014.07.008pdficon

paper Domazet-Lošo T, A Klimovich, B Anokhin, F Anton-Erxleben, M Hamm, C Lange, and TCG Bosch (2014) Naturally occurring tumors in the basal metazoan Hydra.  Nature Communications 5, Article number: 4222 doi:10.1038/ncomms5222 Published 24 June 2014. pdficonSupplementary Information pdficon

paper Fuchs B, W Wang, S Graspeuntner, Y Li, S Insua, EM Herbst, P Dirksen, AM Böhm, G Hemmrich, F Sommer, T Domazet-Loso, U Klostermeier, F Anton-Erxleben, P Rosenstiel, TCG Bosch, and K Khalturin (2014) Regulation of polyp to jellyfish transition in Aurelia aurita. Current Biology, Current Biology 24, 1–11, February 3, 2014 ª2014 Elsevier Ltd All rights reserved http://dx.doi.org/10.1016/j.cub.2013.12.003 pdficon See also Science” News See also Dispatch R159 from Current Biology

2013

paper Franzenburg S, J Walter, S Künzel, JF Baines, TCG Bosch, S Fraune (2013) Distinct antimicrobial tissue activity shapes host species-specific bacterial associations. Proc Natl Acad Sci USA, 110(39):E3730-8 pdficon

Review Boehm AM, P Rosenstiel, and TCG Bosch (2013) Stem cells and aging from a quasi-immortal point of view. BioEssays Vol 35, Issue 11, 35(11):994-1003 pdficon

paper Gehrke S, B Brueckner, A Schepky, J Klein, A Iwen, TCG Bosch, H Wenck, M Winnefeld, S Hagemann (2013) Epigenetic Regulation of Depot-Specific Gene Expression in Adipose Tissue. PLoS ONE 8(12): e82516. doi:10.1371/journal.pone.0082516

Review Bosch Thomas C.G. (2013) Cnidarian-Microbe Interactions and the Origin of Innate Immunity in Metazoans. Ann Rev Microbiol Vol 67, 499-518 pdficon

paper Franzenburg S, S Fraune, P. M. Altrock, S. Künzel, J. F. Baines, A. Traulsen, T.C.G. Bosch (2013) Bacterial colonization of Hydra hatchlings follows a robust temporal pattern.  ISME J. 2013 Apr;7(4):781-90. The article has been selected for Faculty 1000 – F1000Prime. It was recommended as being of special significance in its field.pdficon

paper McFall-Ngai M, M Hadfield, T Bosch, H Carey, T Domazet-Loso, A Douglas, N Dubilier, G Eberl, T Fukami, S Gilbert, U Hentschel, N King, S Kjelleberg, A Knoll, N Kremer, S Mazmanian, J Metcalf, K Nealson, N Pierce, J Rawls, A Reid, E Ruby, M Rumpho, J Sanders, D Tautz, and J Wernegreen (2013). Animals in a bacterial world, a new imperative for the life sciences. Proc Natl Acad Sci U S A. 2013 Feb 26;110(9):3229-36. pdficon

2012

Review Nebel A, Bosch TCG (2012) Evolution of human longevity: lessons from Hydra (Editorial). Aging 4(11):730-731 pdficon

Review Bosch TCG (2012) Bakterien – eher Partner als Feinde; das Immunsystem im Metaorganismus. Biologie in unserer Zeit. Volume 42, Issue 5, pages 302–309, Oktober 2012

paper Boehm AM, G Hemmrich, K Khalturin, M Puchert, F Anton-Erxleben, J Wittlieb, UC Klostermeier, P Rosenstiel, H-H Oberg, and TCG Bosch (2012) FoxO is a critical regulator of stem cell maintenance and immortality in Hydra. Proc Natl Acad Sci USA, 109(48):19697-702  pdficon

Review Fraune S and TCG Bosch (2012) Host-symbiont interactions: why Cnidaria matter.
Cell News 3/2012:14-21

paper Franzenburg S, S Fraune, S Künzel, JF Baines, T Domazet-Lošo, TCG Bosch (2012) MyD88 deficient Hydra reveal ancient function of TLR-signaling in sensing bacterial colonizers. Proc Natl Acad Sci USA 109 (47): 19374-9 pdficon

Review Bosch TCG (2012) Rethinking the origin of multicellularity: Where do epithelia come from? “(Comment on DOI 10.1002/bies.201100187)”. BioEssays 34(10):826-7

paper Fraune J, M Alsheimer, J-N Volff, K Busch, S Fraune, TCG Bosch, R Benavente (2012) Hydra meiosis reveals unexpected conservation of structural synaptonemal complex proteins across metazoans. Proc Natl Acad Sci USA, 109(41):16588-93

Review Bosch TCG (2012) What Hydra has to say about the role and origin of symbiotic interactions. Biological Bulletin, 223: 78-84  pdficon

paper Hemmrich G, K Khalturin, AM Boehm, M Puchert, F Anton-Erxleben, J Wittlieb, UC Klostermeier, P Rosenstiel, HH Oberg, T Domazet-Lošo, T Sugimoto, H Niwa, and TCG Bosch (2012) Molecular signatures of the three stem cell lineages in Hydra and the emergence of stem cell function at the base of multicellularity. Mol. Biol. Evol., doi:10.1093/molbev/mss13  pdficon

Review Bosch TCG (2012) Understanding complex host-microbe interactions in Hydra. Gut Microbes 3:4, 1-7 pdficon

paper Sommer F, S Awazu, F Anton-Erxleben, D Jiang, AV Klimovich, BV Klimovich, MP Samoilovich, Y Satou, M Kruss, C Gelhaus, U Kurn, TCG Bosch and K Khalturin (2012) Blood system formation in the urochordate Ciona intestinalis requires the variable receptor vCRL1 Mol Biol Evol. 2012 May 3. [Epub ahead of print] PMID: 22513285 [PubMed – as supplied by publisher] pdficon

paper Boehm AM and TCG Bosch (2012) Migration of multipotent interstitial stem cells in Hydra. Zoology, 2012 Aug 27. [Epub ahead of print] PMID: 22951272 [PubMed – as supplied by publisher]  ScienceDirect pdficon

paper Brönneke S, B Brückner, N Peters, TCG Bosch, F Stäb, H Wenck, S Hagemann, and M Winnefeld (2012) DNA methylation regulates lineage-specifying genes in the human vascular system. Angiogenesis 15 (2) 317-329

Review Augustin R, Fraune S, Franzenburg S, Bosch TCG (2012) Where simplicity meets complexity: hydra, a model for host-microbe interactions. Adv Exp Med Biol. 2012;710:71-81. Review.

2011

Review Fraune Sebastian, Sören Franzenburg, René Augustin und Thomas C. G. Bosch (2011) Das Prinzip Metaorganismus. BIOSPEKTRUM Volume 17, Number 6, 634-636

paper Forêt S, Seneca F, de Jong D, Bieller A, Hemmrich G, Augustin R, Hayward DC, Ball EE, Bosch TC Agata K, Hassel M, Miller DJ. (2011) Phylogenomics reveals an anomalous distribution of USP genes in metazoans. Mol Biol Evol. 28(1):153-61

Review Fraune S, R Augustin, TCG Bosch (2011) Embryo protection in contemporary immunology: Why bacteria matter. Communicative & Integrative (4):369-72 pdficon

Review Bosch TCG and M McFall-Ngai (2011) Metaorganisms as the new frontier. Zoology 114 (2011) 185–190 pdficon

paper Lange C, G Hemmrich, UC Klostermeier, JA López-Quintero, DJ Miller, T Rahn, Y Weiss, TCG Bosch, and P Rosenstiel (2011) Defining the origins of the NOD-like receptor system at the base of animal evolution. Mol Biol Evol 2011 28: 1687-1702 pdficon

2010

paper Wittlieb J, K Khalturin, TCG Bosch (2010) Transgene Hydra als vielseitiges Modellsystem in “EvoDevo”. Biospektrum 10/2, 186-188.This article was subsequently also included in textbook „Zellbiologie und Mikrobiologie“, Springer Spektrum-Buchpublikation ( Ed. Dieter Jahn), 2012.

paper Anokhin B., G. Hemmrich-Stanisak , T.C.G. Bosch (2010) Karyotyping and single-gene detection using fluorescence in situ hybridization on chromosomes of Hydra magnipapillata (Cnidaria). Comparative Cytogenetics 4(2),97-110

paper Fraune S, R Augustin, F Anton-Erxleben, Jörg Wittlieb, C Gelhaus, V. B. Klimovich,M. P. Samoilovich, and T.C.G. Bosch (2010) In an early branching metazoan, bacterial colonization of the embryo is controlled by maternal antimicrobial peptides Proc. Natl. Acad. Sci. USA , 107,18067-18072 pdficon Featured as “Research Highlights” in Nature Immunology (2010) 11, 1083 pdficon

Review Augustin R and Bosch TCG (2010) Cnidarian Immunity: A Tale of Two Barriers K. Söderhäll (ed.) Invertebrate Immunity Landes Bioscience and Springer Science+Business Media, Review.

Review Fraune S and TCG Bosch (2010) Why bacteria matter in animal development and evolution. Bioessays 32: 571–580 pdficon

paper Bosch TCG, Anton-Erxleben F, Hemmrich G, Khalturin K (2010)The Hydra polyp: Nothing but an active stem cell community.Dev Growth Differ. 52(1): 15-25 pdficon

paper Chapman JA , EF Kirkness, O Simakov, … K Khalturin, G Hemmrich, A Franke, R Augustin, S Fraune, … JC Venter, U Technau,B Hobmayer, TCG Bosch, TW Holstein, T Fujisawa, HR Bode, CN David, DS Rokhsar, RE Steele (2010)The dynamic genome of Hydra. Nature 464 (7288): 592-596 pdficon

paper Gee L,  J Hartig, L Law, J Wittlieb, K Khalturin, TCG Bosch, and HR Bode (2010) Beta-catenin plays a central role in setting up the head organizer in hydra. Dev. Biol., 340 (2010) 116–124 pdficon

Review Augustin R, Fraune S, and TCG Bosch (2010) How Hydra senses and destroys microbes. Seminars in Immunology 22(2010), 54-58.pdficon

2009

paper Augustin R, Anton-Erxleben F, Jungnickel S, Hemmrich G, Spudy B, Podschun R, and TCG Bosch (2009) Activity of the novel peptide Arminin against multiresistant human pathogens shows the considerable potential of phylogenetically ancient organisms as drug sources. Antimicrobial Agents and Chemotherapy 53(12), 5245-5250.

Review Fraune S, Augustin R, and TCG Bosch (2009) Exploring host-microbe interactions in hydra. Microbe 4(10), 457-462.

Review Khalturin K, Hemmrich G, Fraune S, Augustin R, and TCG Bosch (2009) More than just orphans: are taxonomically restricted genes important in evolution? Trends in Genetics, 25(9), 404-413

paper Fraune S, Abe Y, and TCG Bosch (2009) Disturbing epithelial homeostasis in the metazoan Hydra leads to drastic changes in associated microbiota. Environ Microbiol. 11(9):2361-9.

Review Bosch TCG (2009) Evolutionäres Vermächtnis: Stammzellen in Hydra. Biologie In Unserer Zeit 2/2009 (39), 114 – 122. DOI:10.1002/biuz.200910390

Review Rosenstiel P, Philipp E, Schreiber S and TCG Bosch (2009) Evolution and Function of Innate Immune Receptors – Insights from Marine Invertebrates. J Innate Immun 1:291 – 300

paper Takahashi T, Koizumi O, Hayakawa E, Minobe S, Suetsugu R, Kobayakawa Y, Bosch TC, David CN, Fujisawa T. (2009) Further characterization of the PW peptide family that inhibits neuron differentiation in Hydra. Dev Genes Evol, 219(3), 119-129

paper Augustin R, Siebert S, and TCG Bosch (2009) Identification of a kazal-type serine protease inhibitor with potent anti-staphylococcal activity as part of hydra’s innate immune system. Dev Comp Immunology, 33(7), 830-837

Review Bosch Thomas C. G. (2009) Hydra and the evolution of stem cells. BioEssays, 31(4), 478-486

paper Milde S, Hemmrich G, Anton-Erxleben F, Khalturin K, Wittlieb J, and TCG Bosch (2009) Characterization of taxonomically-restricted genes in a phylum-restricted cell type. Genome Biol. 10(1):R8

paper Siebert S, Anton-Erxleben F, Kiko R, Kramer M (2009) Sympagohydra tuuli (Cnidaria, Hydrozoa): first report from sea ice of the central Arctic Ocean and insights into histology, reproduction and locomotion. Mar Biol, 156(4), 541-554.

paper Jung S, Dingley AJ, Augustin R, Anton-Erxleben F, Stanisak M, Gelhaus C, Gutsmann T, Hammer MU, Podschun R, Leippe M, TCG Bosch and Grötzinger J (2009) Hydramacin-1: Structure and antibacterial activity of a protein from the basal metazoan hydra. J Biol Chem, 284(3), 1896-905.

paper Bosch TCG, R Augustin, F Anton-Erxleben, S Fraune, G Hemmrich, H Zill, P Rosenstiel, G Jacobs, S Schreiber, M Leippe, M Stanisak, J Grötzinger, S Jung, R Podschun, J Bartels, J Harder, J-M Schröder (2009). Uncovering the Evolutionary History of Innate Immunity: the Simple Metazoan Hydra Uses Epithelial Cells for Host Defence. Dev Comp Immunol. 33 (2009), 559-569

2008

paper F Anton-Erxleben, A Thomas, J Wittlieb, S Fraune, and TCG Bosch (2008). Plasticity of epithelial cell shape in response to upstream signals: a whole-organism study using transgenic Hydra. Zoology, 112(3): 185-194

paper K Khalturin, F Anton-Erxleben, S Sassmann, J Wittlieb, G Hemmrich, and TCG Bosch (2008). A novel gene family controls species-specific morphological traits in Hydra. PLoS Biology 6 (11): e278 see also the  “Tentacles test tenets of evolution” commentary in “The Scientist” Featured as “Research highlights” in Nature Reviews Genetics January 2009 Volume 10 Number 1

book Bosch TCG (2008) The Path Less Explored: Innate Immune Reactions in Cnidarians. In: H. Heine (ed.), Innate Immunity of Plants, Animals, and Humans. Nucleic Acids and Molecular Biology 21. Springer-Verlag Berlin Heidelberg. Review.

book Khalturin K, U Kürn, and TCG Bosch (2008) Immune Reactions in the Vertebrates’ Closest Relatives, the Urochordates. In: H. Heine (ed.), Innate Immunity of Plants, Animals, and Humans. Nucleic Acids and Molecular Biology 21. Springer-Verlag Berlin Heidelberg. Review.

Review Hemmrich G and Bosch TCG (2008) Compagen, a comparative genomics platform for early branching metazoan animals, reveals early origins of genes regulating stem cell differentiation. BioEssays 20(10), 1010-1018

paper Schwarz RS, Bosch TCG and Cadavid LF (2008) Evolution of polydom-like molecules: Identification and characterization of cnidarian polydom (Cnpolydom) in the basal metazoan Hydractinia Dev Comp Immun. 32, 1192-1210

book Bosch Thomas C. G. (Ed.) (2008) “Stem Cells: From Hydra to Man”. 192 pages. Springer Netherlands (2008) ISBN-10: 1402082738; ISBN-13: 978-1402082733

2007

paper Siebert S, Anton-Erxleben F and Bosch TCG (2007) Cell type complexity in the basal metazoan Hydra is maintained by both stem cell based mechanisms and transdifferentiation. Dev. Biol. 313: 13-24

Review Hemmrich G, Miller DJ and Bosch TCG (2007) The evolution of immunity – A low life perspective. Trends Immunol., 28(10), 449-454

paper Fraune S and Bosch TCG (2007) Long-term maintenance of species-specific bacterial microbiota in the basal metazoan Hydra. Proc. Natl. Acad. Sci. USA 104, 13146-13151

paper Khalturin K, Anton-Erxleben F, Milde S, Plötz C, Wittlieb J, Hemmrich G and Bosch TCG (2007) Transgenic stem cells in Hydra reveal an early evolutionary origin for key elements controlling self-renewal and differentiation. Dev. Biol. 309: 32-44

paper Hemmrich G, Anokhin B, Zacharias H and Bosch TCG (2007) Molecular phylogenetics in Hydra, a classical model in evolutionary developmental biology. Mol. Phylogenet. Evol. 44:281-290

paper Kürn U, Sommer F, Bosch TCG and K Khalturin (2007) In the urochordate Ciona intestinalis zona pellucida domain proteins vary among individuals. Dev. Comp. Immun. 31: 1242-1254

paper Miller DJ, Hemmrich G, Ball EE, Hayward DC, Khalturin K, Funayama N, Agata K and Bosch TCG (2007) The innate immune repertoire in Cnidaria – ancestral complexity and stochastic gene loss. Genome Biol. 8(4):R59

book Bosch TCG (2007) Symmetry breaking in stem cells of the basal metazoan Hydra. In: Asymmetric cell division Series: Progress in Molecular and Subcellular Biology (Ed. Macieira-Coelho). pp. 61-78, Springer, Heidelberg.

Review Bosch TCG (2007) Why polyps regenerate and we don´t: towards a cellular and molecular framework for Hydra regeneration. Dev. Biol. 303:421-433

2006

Review Khalturin K and Bosch TCG (2006) Self / nonself discrimination at the basis of chordate evolution: limits on molecular conservation. Curr. Opin. Immunol. 18:1-6

paper Kürn U, Sommer F, Hemmrich G, Bosch TCG and Khalturin K (2006) Allorecognition in urochordates: identification of a highly variable complement receptor-like protein expressed in follicle cells of Ciona. Dev. Comp. Immun. 31(4):360-71

paper Augustin R, Franke A, Khalturin K, Kiko R, Siebert S, Hemmrich G and Bosch TCG (2006) Dickkopf related genes are components of the positional value gradient in Hydra. Dev. Biol. 296: 62-70

paper Wittlieb J, Khalturin K, Lohmann JU, Anton-Erxleben F and Bosch TCG (2006) Transgenic Hydra allow in vivo tracking of individual stem cells during morphogenesis. Proc. Natl. Acad. Sci. USA 103;16: 6208-6211 see also the commentary “Trembley´s polyps go transgenic” in PNAS 103 (17): 6415-6416

paper Genikhovich G, Kürn U, Hemmrich G and Bosch TCG (2006) Discovery of genes expressed in Hydra embryogenesis. Dev. Biol. 15;289(2): 466-81

paper Thomsen S and Bosch TCG (2006) Foot differentiation and genomic plasticity in Hydra: lessons from the PPOD gene family. Dev. Genes and Evol. 216(2):57-68

2005

paper Siebert S, Thomsen S, Reimer MM, Bosch TCG (2005) Control of foot differentiation in Hydra: phylogenetic footprinting indicates interaction of head, bud and foot patterning systems. Mech. Dev. 122(9):998-1007

paper Habetha M and Bosch TCG (2005) Symbiotic Hydra express a plant-like peroxidase gene during oogenesis. J. Exp. Biol. 208:2157-2164

paper Khalturin K, Kürn U, Pinnow N and Bosch TCG (2005) Towards a molecular code for individuality in the absence of MHC: screening for individually variable genes in the urochordate Ciona intestinalis. Dev. Comp. Immunol. 29(9):759-773

2004

paper Khalturin K, Pancer Z, Cooper MD and Bosch TCG (2004) Recognition strategies in the innate immune system of ancestral chordates. Mol. Immunol. 41(11):1077-1087

Review Bosch TCG (2004) Control of asymmetric cell divisions: will cnidarians provide an answer? BioEssays 26(9):929-931

paper Zacharias H, Anokhin B, Khalturin K and Bosch TCG (2004) Genome sizes and chromosomes in the basal metazoan Hydra Zoology 107(3): 219–227

paper Thomsen S, Till A, Beetz C, Wittlieb J, Khalturin K and Bosch TCG (2004) Control of foot diffenrentiation in Hydra: in vitro evidence that the NK-2 homeobox factor CnK-2 autoregulates its own expression and uses pedibin as target gene. Mech. Dev. 121(2): 195-204

paper Fedders H, Augustin R and Bosch TCG (2004) A Dickkopf-3 related gene is expressed in differentiating nematocytes in the basal metazoan Hydra. Dev. Genes Evol. 214(2):72-80

2003

paper Fröbius AC, Genikhovich G, Kürn U, Anton-Erxleben F and Bosch TCG (2003) Expression of developmental genes during early embryogenesis of Hydra. Dev. Genes Evol. 213(9):445-455

paper Kuznetsov SG and Bosch TCG (2003) Self/nonself recognition in Cnidaria: contact to allogeneic tissue does not result in elimination of nonself cells in Hydra vulgaris. Zoology 106(2):109-116

paper Habetha M, Anton-Erxleben F, Neumann K and Bosch TCG (2003) The Hydra viridis / Chlorella symbiosis. (I) Growth and sexual differentiation in polyps without symbionts. Zoology 106(2):101-108

paper Khalturin K, Becker M, Rinkevich B and Bosch TCG (2003) Urochordates and the origin of natural killer cells: identification of a CD94 / NKR-P1 related receptor in blood cells in Botryllus. Proc. Natl. Acad. Sci. USA 21;100(2): 622-6272 See also: Science, Editors` Choice,Vol.299 Journal of Cell Biology, Research Roundup, Vol.160

Review Bosch TCG (2003) Ancient signals: peptides and the interpretation of positional information in ancestral metazoans. Comp. Biochem. Physiol. Part B: Biochemistry and Molecular Biology 136, 185-196

paper Kasahara S and Bosch TCG (2003) Enhanced antibacterial activity in Hydra polyps lacking nerve cells. Dev. Comp. Immunol. 27: 79-166

paper Khalthurin K, Kuznetsov S and Bosch TCG (2003) PCR Fluorescence Differential Display. PCR Protocols, 2nd edition (eds. J Bartlett & D Stirling) Humana Press, Totowa, New Jersey.

2002

paper Kuznetsov SG, Anton-Erxleben F and Bosch TCG (2002) Epithelial interactions in Hydra: apoptosis in interspecies grafts is induced by detachment from the extracellular matrix. J. Exp. Biol. 205(24):3809-3817

paper Bosch TCG, Augustin R, Gellner K, Khalturin K and Lohmann JU (2002) In vivo electroporation for genetic manipulations of whole Hydra polyps. Differentiation 70(4-5):140-147

Review Bosch TCG and Khalturin K (2002) Patterning and cell differentiation in Hydra: novel genes and the limits to conservation. Canadian Journal of Zoology 80:1670-1677

2001

paper Kuznetsov S, Lyanguzowa M and Bosch TCG (2001) Role of epithelial cells and programmed cell death in Hydra spermatogenesis. Zoology 104(1):25-31

Review Bosch TCG (2001) Neue Tricks von alten Tieren: wie bildet Hydra einen Kopf? BIOforum, 1-2/2001, 57-59.

Review Bosch TCG and Fujisawa T (2001) Polyps, peptides and patterning. BioEssays 23(5) 420-427

2000

paper M Cardenas, Y Fabila, S Yum, J Cerbon, F Böhmer, R Wetzker, T Fujisawa, TCG Bosch, and LM Salgado (2000) Selective protein kinase inhibitors block head-specific differentiation in hydra. Cellular Signalling 12, 649-658

paper Lohmann Jan U. and TCG Bosch (2000) The novel peptide HEADY specifies apical fate in a simple, radially symmetric metazoan. Genes and Development, 14 (21) 2771-2777 Comments in Nature Reviews Genetics (2000) 1: 16; Scientific American Online, The Scientist (2000) 14(23): 24; Bild der Wissenschaft, u.a.

paper Venturelli CR., S Kuznetsov, LM. Salgado, TCG Bosch (2000) An IQGAP-related gene is activated during tentacle formation in the simple metazoan Hydra. Dev Gene Evol 210 (2000) 8/9, 458-463

paper Takahashi T, O Koizumi, Y Ariura, A Romanovitch, TCG Bosch, Y Kobayakawa, S Mohri, HR Bode, S Yum, M Hatta and T Fujisawa (2000) A novel neuropeptide, Hym-355, positively regulates neuron differentiation in Hydra. Development, 127 (5): 997-1005

1999

paper Lohmann Jan U., Ingrid Endl, and TCG Bosch (1999) Silencing of developmental genes in Hydra. Developmental Biology, 214: 211-214

paper Kumpfmüller G, V Rybakine, T Takahashi, T Fujisawa and TCG Bosch (1999) Identification of an astacin matrix metalloprotease as target gene for Hydra foot activator peptides. Development, Genes and Evolution, 209, 601-607.

paper Endl I, J Lohmann and TCG Bosch (1999) Head specific gene expression in Hydra: Complexity of DNA / protein interactions at the promoter of ks1 is inversely correlated to the head activation potential. Proc. Natl. Acad. Sci. USA 96, 1445-1450.

paper Tom M, J Douek, I Yankelevich, TCG Bosch, and B Rinkevich (1999) Molecular characterization of the first heat shock protein 70 from a reef coral. Biochem. Biophys. Res. Commun., 262, 103-108

paper Reinhardt B, U Frank, K Gellner, JU Lohmann, and TCG Bosch (1999) High-resolution, fluorescence-based differential display on a DNA sequencer followed by band excision. BioTechniques, 27 (2) 268-270.

Review Bosch TCG (1999) Neue Wege in der Genanalyse. Laborpraxis 10, 20-22.

book Bosch TCG and J Lohmann (1999) Non-radioactive differential display of messenger RNA. In: Methods in Molecular Biology The Nucleic Acid Protocols Handbook (ed. Ralph Rapley) Humana Press, Totowa, New Jersey.

book Lohmann J and TCG Bosch (1999) Non-radioactive differential display and isolation of mRNA In Expression Genetics: Differential Display (eds A Pardee and M McClelland). Eaton Publishing.

1998

paper Darmer D, F Hauser, HP Nothacker, TCG Bosch , M Williamson and CIP Grimmelikhuijzen (1998) Three different prohormones yield a variety of Hydra-RFamide (Arg-Phe-NH2) neuropeptides in Hydra magnipapillata Biochemical Journal 332, 403-412.

paper Bals R, U Welsch, and TCG Bosch (1998) Molecular characterization of serous and mucous gland cells of the porcine airways American Journal Respiratory Cell and Molecular Biology 18(4), 548-553

paper Brennecke T, K Gellner, and TCG Bosch (1998) The lack of a stress response in Hydra oligactis is due to reduced hsp70 mRNA stability. Eur. J. Biochem. 255, 703-709.

book Bosch TCG (1998) „Hydra“. In Cellular and Molecular Basis of Regeneration From Invertebrates to Humans (eds. P. Ferretti & J. Géraudie). Wiley & Sons Ltd., Sussex. ISBN 0471-97271-1.

book Bosch TC and Lohmann JU (1998) Identification of differentially expressed genes by nonradioactive differential display of messenger RNA. Methods in Molecular Biology. RNA Isolation & Characterisation Protocols Chapter 86 (ed. Ralph Rapley). Humana Press, Totowa, pp. 153-60 .

1997

paper Levi L, J Douek, M Osman, TCG Bosch and B Rinkevich (1997) Cloning and characterization of BS-cadherin, a novel cadherin from the colonial urochordate Botryllus schlosseri. Gene, 200, 117-123.

paper Takahashi T, Y Muneoka, J Lohmann, M de Haro, TCG Bosch, C David, H Bode, O Koizumi, H Shimizu, M Hatta, T Fujisawa, and T Sugiyama (1997) Systematic isolation of peptide signal molecules regulating development in hydra: LWamide and PW families. Proc. Natl. Acad. Sci. USA, 94, 1241-1246.

Review Lohmann J, G Solleder und TCG Bosch (1997) Identifikation differentiell exprimierter Gene. Laborpraxis 10, 18-21.

Review Lohmann J, HP Schickle and TCG Bosch (1997) Nicht-radioaktive “Differential Display” PCR mit horizontalen Polyacrylamidgelen. Laborpraxis 2, 74-78.

1996

book Bosch TCG and J Lohmann (1996) Non-radioactive differential display of messenger RNA. Fingerprinting Methods Based on Arbitrarily Primed PCR. Springer Lab Manual (eds. MR Micheli & R Bova). Springer Verlag, Heidelberg. ISBN 3-540-61229-7.

1995

paper Bosch TCG, E Benitez, K Gellner, G Praetzel and LM Salgado (1995) Cloning of a ras related gene from Hydra which responds to head specific signals. Gene, 167, 191-195.

paper Lohmann J, HP Schickle and TCG Bosch (1995) REN, a rapid, efficient and non-radioactive method for differential display and isolation of mRNA. BioTechniques 18(2): 200-202

1994

paper Weinziger R, Salgado LM, CN David and TCG Bosch (1994). Ks1, an epithelial cell specific gene, responds to early signals of head formation in Hydra. Development 120, 2511-2517.

paper Lopez de Haro M, LM Salgado, CN David, TCG Bosch (1994). Hydra tropomyosin Trop1 is expressed in head specific epithelial cells and is a major component of the cytoskeletal structure which anchors nematocytes. J Cell Sci, 107, 1403-1411.

paper Bolzer A, RM Melzer, TCG Bosch (1994) A SEM analysis of DMSO treated hydra polyps. Biol. Cell, 81, 83-86.

1992

paper Gellner K, G Praetzel and TCG Bosch (1992) Cloning and expression of an heat inducible hsp70 gene in two species of hydra which differ in their stress response. Eur. J. Biochem. 210, 683-691.

1991

paper David CN, T Fujisawa and TCG Bosch (1991) Interstitial stem cell proliferation in hydra: evidence for strain specific regulatory signals. Dev. Biol. 148, 501-507.

paper Bosch TCG, R Rollbühler, B Scheider and CN David (1991) Role of the cellular environment in interstitial stem cell proliferation in hydra. Roux’s Arch Dev Biol. 200, 269-276

paper Bosch TCG and G Praetzel (1991) The heat shock response in hydra: immunological relationship of HSP60, the major heat shock protein of Hydra vulgaris PALLAS, to the ubiquitous HSP70 family. Hydrobiol 216/217, 513-517.

book Bosch TCG, KL Gellner and G Praetzel (1991) The heat shock response in the freshwater polyp Hydra. “Heat shock ” (Eds. Maresca & Lindquist), Springer Verlag.

Review Bosch TCG and CN David (1991) Decision making in interstitia In Vivo 5, 515-520

1990

paper Fujisawa T, CN David and TCG Bosch (1990) Transplantation stimulates interstitial cell migration in hydra. Dev. Biol 138, 509-512.

paper Bosch TCG and CN David (1990) Cloned interstitial stem cells grow as contiguous patches in hydra. Dev. Biol. 138, 513-515.

1989

paper Bosch TCG, TF Unger, DA Fisher, RE Steele (1989) Structure and expression of STK, a src related gene in the simple metazoan hydra. Mol. Cell Biol. 9(10), 4141-4151. 1988

paper Bosch TCG, SM Krylow, HR Bode, RE Steele (1988) Thermotolerance and synthesis of heat shock proteins: These responses are present in Hydra attenuata but absent in Hydra oligactis. Proc. Natl. Acad. Sci. USA 85, 7927-7931.

1987

paper Bosch TCG and CN David (1987) Stem cells of Hydra magnipapillata can differentiate into somatic cells and germ line cells. Dev.Biol.121, 182-191.

R: David CN, TCG Bosch, B Hobmeyer, T Holstein, T Schmidt (1987) Interstitial stem cells in hydra. “Genetic control of development”, Alan R Liss, New York. p 389.

1986

paper Bosch TCG and CN David (1986). Male and female stem cells and sex reversal in Hydra polyps. Proc. Nat. Acad. Sci. USA. 83, 9478-9482.

paper Bosch TCG and CN David (1986). Immunocompetence in Hydra: Epithelial cells recognize self-nonself and react against it. J.Exp.Zool.238, 225-234.

1984

paper Bosch TCG and CN David (1984) Growth regulation in Hydra: Relationship between epithelial cell cycle length and growth rate. Dev.Biol. 104, 161-171.