Postdoc Sebastian Fraune was offered a position as tenured professor at the University of Düsseldorf. Congratulation, Sebastian!
Spontaneous contractions of the digestive tract play an important role in the vast majority of organisms in order to ensure a healthy intestinal function. From simple invertebrates to humans, there are consistently similar movement patterns that transport and mix the contents of the intestine through the rhythmic contraction of the muscles. These contractions of the intestine are indispensable for the digestive process and are referred to in science as peristalsis. In various diseases of the digestive tract, for example, serious inflammatory bowel disease in humans, there are disorders of natural peristalsis. So far, little is explored by which factors these contractions are controlled.
Ph.D. student Andrea Murillo together with postdoc Alexander Klimovich and other members of the Bosch lab could prove for the first time that bacterial colonization plays an important role in peristalsis in the freshwater polyp Hydra. The observation that microorganisms within the gut can affect essential pacemaker functions in peristalsis are published in the journal “Scientific Reports”.
López-Quintero JA, Torres GG, Neme R, Bosch TCG (2019) Boundary maintenance in the ancestral metazoan Hydra depends on histone acetylation. Developmental Biology, https://doi.org/10.1016/j.ydbio.2019.11.006
Rausch P, Rühlmann M, … Bosch TCG, Baines JF (2019) Comparative analysis of amplicon and metagenomic sequencing methods reveals key features in the evolution of animal metaorganisms. Microbiome, in press
Johnke J, Fraune S, Bosch TCG, Hentschel U, Schulenburg H (2019) Bdellovibrio and Like Organisms are Predictors of Microbiome Diversity in distinct Host Groups. Microbial Ecology, Microb Ecol. 2019 Jun 11. doi: 10.1007/s00248-019-01395-7
Klimovich A, Wittlieb J, Bosch TCG (2019) Transgenesis in Hydra to characterize gene function and visualize cell behaviour. Nature Protocol, https://rdcu.be/bFvBI
Sieber M, Pita L, Weiland-Bräuer N, Dirksen P, Wang J, Mortzfeld B, Franzenburg S, Schmitz RA, Baines JF, Fraune S, Hentschel U, Schulenburg H, Bosch TCG, and Traulsen A (2019): Neutrality in the Metaorganism. PLoS Biol, 2019 Jun 19;17(6):e3000298
Lachnit T, Bosch TCG, Deines P (2019): Exposure of the host-associated microbiome to nutrient-rich conditions may lead to dysbiosis and disease development – an evolutionary perspective. mBio 10:e00355-19.
Bosch TCG (2019) Squid genomes in a bacterial world. Proc Natl Acad Sci USA. 116(8):2799-2801. doi: 10.1073/pnas.1822166116. (Comment on “Symbiotic organs shaped by distinct modes of genome evolution in cephalopods”, Proc Natl Acad Sci U S A. 2019)
Jaspers C, Fraune S, Consortium of Australian Academy of Science Boden Research Conference Participants, Arnold AE, Miller DJ, Bosch TCG, Voolstra CR (2019) Resolving structure and function of metaorganisms through a holistic framework 2 combining reductionist and integrative approaches. Zoology, 133:81-87. doi: 10.1016/j.zool.2019.02.007
Bosch TCG, Guillemin K, McFall-Ngai M (2019) Evolutionary “experiments” in symbiosis: the study of model animals provides insights into the mechanisms underlying diversity of host-microbe interactions”. BioEssays, e1800256
Rees T, Bosch TCG, AE Douglas (2018) The Microbiome and the Human: A Reply to Parke et al. PLoS Biol 16(9): e2006974. doi.org/10.1371/journal.pbio.2006974
von Frieling J, Fink C, Hamm J, Klischies K, Forster M, Bosch TCG, Roeder T, Rosenstiel P, Sommer F (2018). Grow with the challenge – microbial effects on epithelial proliferation, carcinogenesis and cancer therapy. Front Microbiol., 9:2020. doi: 10.3389/fmicb.2018.02020
Klimovich, A. V. and Bosch, T. C. (2018), Rethinking the Role of the Nervous System: Lessons From the Hydra Holobiont. BioEssays. . doi:10.1002/bies.201800060
Hamada M, Schröder K, Bathia J, Kürn U, Fraune S, Khalturina M, Khalturin K, Shinzato C, Satoh N, Bosch TCG (2018) Metabolic co-dependence drives the evolutionarily ancient Hydra-Chlorella symbiosis. eLife 2018;7:e35122 https://doi.org/10.7554/eLife.35122
Klimovich A, Rehm A, Wittlieb J, Herbst E, Benavente R, Bosch TC, . Non-senescent Hydra tolerates severe disturbances in the nuclear lamina. Aging (Albany NY). 2018; 10:951-972. https://doi.org/10.18632/aging.101440
Bang, C, Dagan T, Deines P, Dubilier N, Duschl WJ, Fraune S, Hentschel U, Hirt H, Hülter N, Lachnit T, Picazo D, Pita L, Pogoreutz C, Radecker N, Saad MM, Schmitz RA, Schulenburg H, Voolstra CR, Weiland-Brauer N, Ziegler M, Bosch TCG (2018). Metaorganisms in extreme environments: do microbes play a role in organismal adaptation? Zoology 127 (2018), 1-19